Y Synthesis, characterization, and in vitro effect of the Cu(II) complex with niflumic acid and 3-picoline on paraoxanase-I

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dc.authoridDilek, Esra/0000-0002-3629-5168
dc.contributor.authorDilek, Esra
dc.contributor.authorCaglar, Sema
dc.contributor.authorCardak, Seda
dc.contributor.authorKarakoc, Baris
dc.contributor.authorCaglar, Bulent
dc.contributor.authorSahin, Onur
dc.date.accessioned2025-03-23T19:47:15Z
dc.date.available2025-03-23T19:47:15Z
dc.date.issued2019
dc.departmentSinop Üniversitesi
dc.description.abstractNiflumic acid is used to treat inflammatory rheumatoid diseases, pain, and fever. The present study reports the experimental, spectroscopic, thermal, structural analyses, and biological activities of this complex. The nonsteroidal anti-inflammatory drug niflumic acid, 3-picoline, and copper(II) chloride were utilized to synthesize a new complex: [Cu2Cl2(nif)(2)(3-pic)(4)]. The crystal structure of [Cu2Cl2(nif)(2)(3-pic)(4)] was determined by X-ray crystallography. The complex crystallizes in the triclinic space group P-1 and each Cu(II) center displayed six-coordinated distorted octahedral geometry. Two Cu(II) centers are connected by a chloro-bridge to form the binuclear metal core. Finally, the in vitro effects of the synthesized new complex and free niflumic acid were evaluated on the human serum paraoxonase 1 enzyme. At low doses, both the new complex and free niflumic acid showed very good inhibition activity with different inhibition mechanisms. In addition, the results showed that the new complex has more inhibition activity than free niflumic acid.
dc.identifier.doi10.1002/ardp.201900007
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.issue6
dc.identifier.pmid31066105
dc.identifier.scopus2-s2.0-85066306455
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/ardp.201900007
dc.identifier.urihttps://hdl.handle.net/11486/7321
dc.identifier.volume352
dc.identifier.wosWOS:000470905700009
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofArchiv Der Pharmazie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectcopper(II) complex
dc.subjectcrystal structure
dc.subjectenzyme inhibition
dc.subjectniflumic acid
dc.subjectparaoxonase 1
dc.titleY Synthesis, characterization, and in vitro effect of the Cu(II) complex with niflumic acid and 3-picoline on paraoxanase-I
dc.typeArticle

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