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Öğe The effect of thrombosis-related laboratory values on mortality in COVID-19 infection(Verduci Publisher, 2023) Ergenc, Z.; Ergenc, H.; Ozturk, A.; Kaya, T.; Nalbant, A.; Karacaer, C.; Gunay, S.OBJECTIVE: COVID-19 may cause thrombosis in both venous and arterial systems. Familiarity with the signs and symp-toms of thrombosis and its treatment is essen-tial in treating COVID-19 infection and its com-plications. D-Dimer and mean platelet volume (MPV) are measurements related to the devel-opment of thrombosis. This study investigates whether MPV and D-Dimer values could be used to determine the risk of thrombosis and mortali-ty in the COVID-19 early stages.PATIENTS AND METHODS: 424 patients who were COVID-19 positive, according to the World Health Organization (WHO) guidelines, were randomly and retrospectively included in the study. Demographic and clinical character-istics such as age, gender, and length of hospi-talization were obtained from the digital records of participants. Participants were divided into living and deceased groups. The patients' bio-chemical, hormonal, and hematological param-eters were analyzed retrospectively.RESULTS: White blood cells (WBC), neutro-phils, and monocytes were significantly differ-ent in the two groups (p-value <0.001), and their values were lower in the living group than in the deceased group. MPV median values did not dif-fer according to prognosis (p-value = 0.994). While the median value was 9.9 in the survivors, it was 10 in the deceased. Creatinine, procalci-tonin, ferritin, and the number of hospitalization days in living patients were significantly lower than in patients who died (p-value <0.001). Me-dian values of D-dimer (mg/L) differ according to prognosis (p-value <0.001). While the median value was 0.63 in the survivors, it was found as 438 in the deceased.CONCLUSIONS: Our results did not show any significant relationship between the mortality of COVID-19 patients and their MPV levels. How-ever, a significant association between D-Di-mer and mortality in COVID-19 patients was ob-served.Öğe Plantago major Protective Effects on Antioxidant Status after Administration of 7,12-Dimethylbenz(a)anthracene in Rats(Asian Pacific Organization Cancer Prevention, 2011) Oto, Gokhan; Ekin, Suat; Ozdemir, Hulya; Demir, Halit; Yasar, Semih; Levent, Abdulkadir; Berber, IsmetAim: The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA). Methods: Rats were divided into three equal groups of 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and group 3 receiving the DMBA and the aqueous extract at 100 mg/kg/d for 60 days. Results: Significant decrease in catalase (P<0.05), carbonic anhydrase (p <= 0.01), reduced glutathione (GSH) (P<0.01) and total protein (P<0.01) values was observed in the DMBA group compared with the healthy controls and DMBA + Plantago major groups. Conclusion: The results suggest preventive effects of Plantago major on DMBA induced oxidative damage in Wistar albino rats that might be due to decreased free radical generation.Öğe Electrophysiological and histopathological effects of mesenchymal stem cells in treatment of experimental rat model of sciatic nerve injury(E-Century Publishing Corp, 2015) Yarar, Ercan; Kuruoglu, Enis; Kocabicak, Ersoy; Altun, Adnan; Genc, Eyup; Ozyurek, Hamit; Kefeli, MehmetAim: The aim of this study was to evaluate electrophysiological and histopathological effects of mesenchymal stem cells in treatment of sciatic nerve injury. Material and methods: Thirty-two female Spraque-Dawley rat were used in this study. Eight rats were used as a reference group in electrophysiological analysis for evaluation of non-injured nerve recordings (Control Group). Twenty-four rats were used for experimental evaluation. Twelve rats were anastomosed without treatment with mesenchymal stem cells (Sham Group) and twelve other rats were anastomosed and treated with mesenchymal stem cells (Stem Cell Group). Surgicel and bioglue were used in anastomosed line in both Groups. Eight weeks after the surgery, electrophysiological evaluation of rats was performed and, then, rats were decapitated under anesthesia and specimens including sciatic nerves and anastomosed line were taken for histopathological evaluation. Electromyography and nerve conduction velocity testing and histopathological scoring including rate of Wallerian degeneration, and neuroma and scar formation were evaluated for both Groups. Results: There were no statistically significant differences between Sham and Stem Cell Groups with respect to histopathological evaluation. However, nerve conduction velocity showed significant difference between groups (P = 0.001). Nerve conduction velocity was significantly improved in Stem Cell Group when compared to Sham Group. Conclusion: In this study, based on nerve conduction velocity data, it was concluded that treatment with mesenchymal stem cells during end-to-end anastomosis improves functional regeneration.Öğe Finite element analysis of stress distribution of 2 different tooth preparation designs in porcelain-fused-to-metal crowns(Quintessence Publishing Co Inc, 2006) Oyar, P; Ulusoy, M; Eskitascioglu, GPurpose: The aim of this clinical simulation study was to investigate the effect of anatomic and nonanatomic occlusal preparation design on stress distribution in different metal-ceramic crowns and tooth and bone. Materials and Methods: For the finite element analysis method, a 2-dimensional mathematical model of a mandibular second premolar tooth and its supporting tissues was used. The analysis was performed by using a structural analysis program. Four groups were designed: gold-palladium alloy/anatomic occlusal preparation (Au-Pd/A), Au-Pd alloy/nonanatomic (flat) occlusal preparation (Au-Pd/N), nickel-chromium alloy/anatomic occlusal preparation (Ni-Cr/A), and Ni-Cr alloy/nonanatomic occlusal preparation (Ni-Cr/N). A distributed type load of 400 N (total) was applied to the centric stop points on the tip of the buccal cusp and on the central developmental groove in centric occlusion to all types of restorations. Results: The results demonstrated that shear stresses in the dentin tissues and restorations in Au-Pd/A and Ni-Cr/A were similar. The shear stresses within the restorations in Au-Pd/N and Ni-Cr/N were similar. Conclusion: Anatomic occlusal preparation designs were advantageous in stress distribution in the dentin tissue. Nonanatomic occlusal preparation designs were found to be advantageous in the stress amount and distribution in the porcelain structure. Occlusal preparation designs and restorative materials showed no differences in stress distribution and amount in the pulp tissue and bone tissues.Öğe Method Validation and Simultaneous Determination of Retinol, Retinyl Palmitate, β-Carotene, α-Tocopherol and Vitamin C in Rat Serum Treated with 7,12 Dimethylbenz[a]Anthracene and Plantago major L. by High-Performance Liquid Chromatography Using Diode-Array Detection(Bentham Science Publ Ltd, 2013) Levent, Abdulkadi; Oto, Gokhan; Ekin, Suat; Berber, IsmetA new and simple high-performance liquid chromatography method was developed and validated for the simultaneous determination of retinol, retinyl palmitate, beta-carotene, alpha-tocopherol and vitamin C in rat serum treated with Plantago Major L. and 7,12 dimethylbenz[a] anthracene. High-performance liquid chromatography analysis was performed utilizing an Inertsil ODS3 reversed phase column with methanol-tetrahydrofuran-water as mobile phase under gradient conditions, at 1.5 mL min(-1) flow rate and 25 degrees C. Diode-array detection was at 325, 450, 290 and 270 nm (retinol and retinyl palmitate), beta-carotene, alpha-tocopherol and vitamin C, respectively and runnig time 18 min. The high-performance liquid chromatography assay and extraction procedure proposed are simple, rapid, sensitive and accurate. The method was then applied for the determination of retinol, retinyl palmitate, beta-carotene, alpha-tocopherol and vitamin C in rat serum. Results of this study demonstrated that; at 60th day DMBA-treated group, there was a significant decrease in vitamin levels compared to the levels of control group. A significant increase was observed in vitamin levels of 7,12 dimethylbenz[a]anthracene+Plantago Major L.-treated group compared to the DMBA-treated group. Additionally, the results obtained in the study are found to be in agreement with data reported in the literature.Öğe Total white blood cell count is associated with the presence, severity and extent of coronary atherosclerosis detected by dual-source multislice computed tomographic coronary angiography(Via Medica, 2011) Ates, Ahmet Hakan; Canpolat, Ugur; Yorgun, Hikmet; Kaya, Ergun Baris; Sunman, Hamza; Demiri, Edis; Taher, AliBackground: Total white blood cell (WBC) count has been consistently shown to be an independent risk factor and predictor for future cardiovascular outcomes, regardless of disease status in coronary artery disease (CAD). The purpose of this study is to evaluate the relationship between total WBC count and the presence, severity and extent of coronary atherosclerosis detected in subjects undergoing multislice computed tomographic (MSCT) coronary angiography for suspected CAD. Methods: A total of 817 patients were enrolled in this cross-sectional study. Non-significant coronary plaque was defined as lesions causing <= 50% luminal narrowing, and significant coronary plaque was defined as lesions causing > 50% luminal narrowing. For each segment, coronary atherosclerotic lesions were categorized as none, calcified, non-calcified and mixed. All images were interpreted immediately after scanning by an experienced radiologist. Results: An association between hypertension, diabetes mellitus, age, gender, hyperlipidemia, smoking, total WBC counts and coronary atherosclerosis was found when patients were grouped into two categories according to the presence of coronary atherosclerosis (p < 0.05). Although plaque morphology was not associated with total WBC counts, the extent of coronary atherosclerosis was increased with higher total WBC quartiles (p = 0.006). Patients with critical luminal stenosis had higher levels of total WBC counts when compared to patients with non-critical luminal narrowing (7,982 +/- 2,287 vs 7,184 +/- 1,944, p < 0.05). Conclusions: Our study demonstrated that total WBC counts play an important role in inflammation and are associated with the presence, severity and extent of coronary atherosclerosis detected by MSCT. Further studies are needed to assess the true impact of WBC counts on coronary atherosclerosis, and to promote its use in predicting CAD. (Cardiol J 2011; 18,4: 371-377)Öğe Effect of sildenafil on intestinal adaptation parameters in a rat model of short bowel syndrome(Verduci Publisher, 2016) Bilecik, T.; Ensari, C.; Mayir, B.; Cakir, T.; Minareci, E.; Arslan, U.; Oruc, T.OBJECTIVE: We aimed to evaluate the effect of sildenafil on the intestinal adaptation in short bowel syndrome (SBS). MATERIALS AND METHODS: Forty-eight male Wistar-albino rats (weight, 231-390 g) were randomly divided into four groups with 12 rats in each. Group TA had only ileal transection+anastomosis, Group TA+S was given sildenafil after ileal transection+anastomosis, Group RA had a resection of 75% of the small bowel+anastomosis, Group RA+S was given sildenafil after small bowel resection+anastomosis. Sildenafil was injected subcutaneously at 60 mg/kg/day dose throughout 3-21 days postoperatively. Bowel and mucosal weights, villus height, crypt depth, DNA and protein concentrations were determined. RESULTS: Jejunal bowel weight was lower in TA and TA+S groups than RA and RA+S groups (p < 0.05). RA+S group had higher ileal and jejunal mucosal weights than RA and TA+S groups (p < 0.05). Villus height was highest in RA+S group both in ileum and jejunum (466.1 +/- 38.6 mu m and 648.1 +/- 65.7 mu m, respectively). Jejunal crypt depth was highest in RA+S group (255.1 +/- 21.9 mu m) compared to other groups (p < 0.05). There was no significant difference in ileal and jejunal protein concentration between TA and TA+S groups and in ileal protein concentration between RA ve RA+S groups (p > 0.05). Ileal DNA concentration was higher in TA+S group, and jejunal DNA concentration was higher in RA and RA+S groups than TA and TA+S groups (p < 0.05). CONCLUSIONS: Sildenafil has a positive effect on intestinal adaptation parameters, particularly in jejunum in a rat SBS model. Thus, its role in the treatment of SBS should be further investigated with clinical studies.Öğe Evaluation of diffuse lymphadenopathy via various quantitative PET/CT parameters(Hellenic Soc Nuclear Medicine, 2023) Silov, Guler; Cankaya, Emel; Karacavus, SeyhanObjective: Discovery of diffuse lymphadenopathy (DLAP) in fluorine-18-fluorodeoxyglucose ( F-18-FDG) positron emission tomography/computed tomography (PET/CT) imaging alerts for the existence of many pathologic conditions with severity ranging from benign to malignancy. This study examines the role of various metabolic parameters reflecting F-18-FDG characteristics of organs/tissues to reach an accurate differential diagnosis for further clinical assessment. Materials and Methods: Positron emission tomography/CT images of 78 patients with DLAP were reviewed retrospectively. The diameter of the largest lymph node (DLlyn), maxi- mum standardized uptake value (SUVmax) of the liver (L), the largest lymph node (Llyn), spleen (S), and bone marrow (BM) were measured. Ratios to liver SUVmax were calculated for all, resulting LLRmax, SLRmax, and BMLRmax respectively. Results: The diameter of the largest lymph node, Llyn. SUVmax, LLRmax, and SLRmax produced cut-off values as 25.5, 8.86, 2.80, and 0.82 with corresponding sensitivity: specificity values as 65%:83%, 74%:77%, 74%:71%, and 79%:63% respectively for risk stratification of malignant causes. To differentiate lymphoma from sarcoidosis, DLlyn, SLRmax, and BMLRmax were found valuable with cut-off values obtained as 28.5, 0.84, and 1.19 with corresponding sensitivity: specificity values as 79%:91%, 79%:82%, and 54%:91%, respectively. Interdependency between parameters was also evaluated. Conclusion: High values of Llyn. Maximum SUV and LLRmax are the main characteristics of lymphoma, metastasis, and sarcoidosis. The diameter of the largest lymph node, SLRmax, and BMLRmax are determined as distinct parameters for distinguishing lymphoma from sarcoidosis. Besides, observed correlation structures amongst some PET/CT parameters were identified as nodal, extranodal, and diffuse patterns for three disease groups except sarcoidosis. These findings extend the knowledge about diagnostic factors based on F-18-FDG PET/CT patterns for DLAP.Öğe Symptom prevalance of obstructive sleep apnea-hypopnea syndrome in health-care providers in central Sivas(Turkish Assoc Tuberculosis & Thorax, 2008) Dogan, Omer Tamer; Berk, Serdar; Ozsahin, Sefa Levent; Arslan, Slhattin; Duzenli, Hasan; Akkurt, IbrahimObstructive sleep apnea-hypopnea syndrome (OSAHS) is the most common sleep disorder that can lead to serious complications. Polysomnography (PSG) is the gold standard for the diagnosis of OSAHS. Unfortunately, PSG studies are expensive, time-consuming, requiring special team and equipment. Therefore, it is possible to determine the cases likely to have OSAHS requiring at least PSG by type A studies. There isn't enough data about the prevalence of OSAHS in Turkey. The aim of this study was to estimate the symptom prevalence of OSAHS in health-care providers in central Sivas. The questionnaire asking demographic features, additional diseases, habits, the symptoms related with OSAHS was performed in total of 1202 health care providers. We also performed Epworth sleepiness scale (ESS) to determine excessive daytime sleepiness. Snoring was detected in 267 partitiants. Snoring rates were 38% and 10.9% in men and in women, respectively. The rate of witnessed sleep apnea in all cases was 4.4% (n=53). Witnessed sleep apnea was reported by 42 of men (8.4%) and 11 of women (1.6%). A total of 338 partitiant had excessive daytime sleepiness. There was a significant relation between three major symptoms of OSAHS and excessive sleepiness while driving. All three major symptoms were detected in 22 cases (1.8%), of which 21 were males. This study suggested that OSAHS symptom prevalence is quite high helth-care provides in our region and, therefore expanded usage of PSG studies is required.Öğe The use of the CT90 value in predicting anxiety in OSA: could it be a useful parameter?(Verduci Publisher, 2023) Alkilinc, E.; Ilgazli, A. H.; Boyaci, H.; Basyigit, I.; Baris, S. argun; Ozgun, S.- OBJECTIVE: Obstructive sleep apnea (OSA) is characterized by recurrent epi-sodes of complete or partial obstruction of the upper airway leading to episodic desaturation. OSA patients often show symptoms of anxiety. Our study aimed to examine the presence and levels of anxiety in OSA and simple snoring rel-ative to control subjects and to investigate the correlation between anxiety scores and poly-somnographic, demographic, and sleepiness parameters. SUBJECTS AND METHODS: The study in-cluded 80 OSA, 30 simple snoring, and 98 con-trol cases. Demographic, anxiety, and sleep-iness data of all subjects were acquired. The Beck Anxiety Inventory (BAI) was used to deter-mine the level of anxiety. The Epworth Sleepi-ness Scale (ESS) was used to evaluate the sleep-iness level of participants. In addition, polysom-nography recordings of those in the OSA and the simple snoring group were acquired. RESULTS: Significantly higher anxiety scores were found in patients with obstructive sleep ap-nea and simple snoring compared to the control group (p<0.01, p<0.01, respectively). From the polysomnographic data obtained from OSA and simple snoring subjects, the CT90 values (cu-mulative percentage of the time spent at satu-rations below 90%) and the AHI showed a weak positive correlation between the level of anxi-ety (p=0.004, r=0.271; p=0.04, r=0.196, respec-tively). CONCLUSIONS: Our study concluded that polysomnographic data showing the depth and duration of hypoxia may be more reliable in showing neuropsychological disorder and hy-poxia-related comorbidities in OSA. The CT90 value can be used as a measure in the assess-ment of anxiety in OSA. Its advantage is that it can be measured with overnight pulse oximetry along with in-laboratory PSG and HSAT (home sleep apnea test).Öğe The effects of long-term oxygen therapy on survey in patients with chronic respiratory failure(Turkish Assoc Tuberculosis & Thorax, 2008) Duzenli, Hasan; Dogan, Omer Tamer; Berk, Serdar; Ozsahin, Sefa Levent; Akkurt, IbrahimLong-term (>= 15 hours) oxygen therapy (LTOT) increases life-span and improves quality of life (QOL) in patients with chronic respiratory failure (CRF). However, in our clinical practice, we observed that very few patients are using oxygen therapy 15 hours or more. Furthermore, very few literatures about survival of non-or inadequate oxygen users were found. Thus, the aim of this study was to assess the effect of LTOT in patients with CRF. A total of 305 LTOT recommended patients with CRF in our clinic between 1996 and 2001 were found. A hundred and five patients with documented subject characteristics were included the study and followed-up similar to 20 months prospectively. They were divided into two groups whether to take LTOT (group 1, n= 71) or not (group 2, n= 34). Average life-span of the patients was 50 months in group 1 and 39 months in group 2 (p< 0.05). Survival (months) in group 1 was significantly correlated with hrs of oxygen use (r= 0.684, p= 0.001). One more hour oxygen use was statistically significantly correlated with 0.002 months more survival (F= 48.44, p< 0.05) in group 1 in logistic regression analysis. In comparisons, there were significant improvement in the post-treatment blood gas values in group 1 (p< 0.05). There were significant decreases in PFT values in the post-treatment period when compared to baseline values in both groups (p< 0.05). There was a less decrease in FEV1 values per year in group 1 than group 2 but difference was not statistically significant (p> 0.05). In conclusion our findings revealed that LTOT provides improvement of the life-span of the patients with CRF.Öğe The Effect of Cold Water Immersion on Cardiac Troponin T and Myoglobin Levels(Maghira & Maas Publications, 2019) Cakir, Ergun; Senel, Omer; Arslanoglu, ErkalOBJECTIVES: Skeletal and cardiac damages occurring in the high intensity training, can reduce the efficiency of the athlete in the next training session. Cold water immersion can help for more efficient recovery in athletes. This study was conducted to investigate the effect of cold water immersion applied after exercise on cardiac troponin T and myoglobin levels. MATERIAL AND METHODS: The experimental group comprised of a total of 23 male football players, of which 12 comprised the study group (age 22.4 +/- 3.16 years, height 176.9 +/- 6.08 cm, BMI 22.61 +/- 1.27 kg/m(2)) and 11 comprised the control group (age 21.3 +/- 2.21 years, height 175.8 +/- 5.52 cm, BMI 21.24 +/- 3.15 kg/m(2)).The athletes provided blood samples before exercise (BE) for troponin T (cTnT) and myoglobin (Mb) measurement. Consequently, muscle damage exercise protocol consisting of depth jump, and immediately after this, cold-water immersion at 15 degrees C was applied to experimental group for 10 minutes. The athletes provided blood samples after 2 (2h) and 24 (24h) hours from cold water immersion. Athletes in the control group underwent the same measurements except application of cold-water immersion. RESULTS: While there was a significant difference (p<0.05) between the experimental and the control groups regarding troponin values, no significant difference was found for the myoglobin values (p>0.05). CONCLUSIONS: In this study, cTnT level, which is regarded as one of the most specific markers of cardiac injury, was found to be lower in the athletes who underwent cold water immersion. These results indicate that the recovery time may be shorter in athletes undergoing cold-water immersion.Öğe Prevalence of metabolic syndrome in women with rheumatoid arthritis and effective factors(E-Century Publishing Corp, 2014) Bilecik, Nilufer Aygun; Tuna, Serpil; Samanci, Nehir; Balci, Nilufer; Akbas, HalidePurpose: Metabolic syndrome (MS), which is framed by cardiovascular risk factors such as hypertension, obesity, glucose intolerance and dyslipidemia, is thought to be associated with the rheumatic diseases. The aim of this study is to examine the frequency of metabolic syndrome (MS) and insulin resistance in patients with rheumatoid arthritis (RA) and to examine the effect of the inflammation symptoms, disease activity and drugs used in treating RA on insulin resistance and presence MS. Method: One hundred women patients diagnosed with RA according to the American College of Rheumatology (ACR) diagnosis criteria and 100 healthy women were included in the study as controls. Insulin resistance were evaluated using the homeostasis model assessment for insulin resistance (HOMA-IR) method and MS was diagnosed according to two Metabolic Syndrome definitions (National Cholesterol Education Programme 2004, International Diabetes Federation). The disease activity of RA was evaluated by the disease activity score including 28 joints (DAS28). Results: In total, 27% and 33% of the RA patients and 28% and 44% of the control group patients according to the diagnostic criteria used were also MS patients. There was no significant difference between the RA and control groups in MS frequency and insulin resistance according to two diagnostic criteria used. The DAS28, erythrocyte sedimentation speed (ESS) and serum uric acid levels in the RA patients with MS were significantly higher than those of the RA patients without MS. The prevalence of MS In patients with RA using methotrexate (MTX) was significantly lower than without RA. Other drugs used in treatment of RA had no effect on the prevalence of MS in patients with RA. Conclusion: Controlling inflammation and disease activity can reduce the MS frequency of RA patients and MTX treatment also may be a protective factor against MS.Öğe Mucous retention cysts of the paranasal sinuses(Lithographia, 2014) Bal, M.; Berkiten, G.; Uyanik, E.[No abstract available]Öğe Individual-Level Determinants of Self-Care Behaviors and Adaptation to Chronic Illness in Turkish Patients With Chronic Disease: A Single-Center Cross-Sectional Study(Dove Medical Press Ltd, 2025) Kilic, Yasin Furkan; Gurel, Tugba YardimciPurpose: The study aimed to investigate the relationship between self-care management behaviors of individuals with chronic disease and their adaptation to chronic illness. Methods: This cross-sectional and correlational study was conducted with 312 patients treated at a Training and Research Hospital in Turkey between December 2023 and March 2024. The data were collected using a Sociodemographic Characteristics Form, the Self- Care Management Scale in Chronic Illness (SCMP-G) and the Adaptation to Chronic Illness Scale (ACIS). Results: Mean total scores of the participants for SCMP-G were 107.52 +/- 12.51 and 77.00 +/- 10.00 for ACIS. There was a low-level negative correlation between age and chronic disease adaptation (rh = -0.201; P < 0.001). Adaptation to chronic illness decreased with increasing age. There was a low-level negative correlation between BMI and physical adaptation (rh = -0.127; P = 0.026) and self- guarding (rh = -0.114; P = 0.046). As BMI increased, physical adaptation and self-guarding decreased. Regression analyses revealed that age (beta = -0.115, t = -0.511, P < 0.05) and economic status (beta = 2.698, t = -2.487, P < 0.05) had a significant effect on adaptation to chronic illness. Multiple regression analysis of the effect of self-guarding and social guarding variables on adaptation to chronic illness was significant (F = 3.504, P < 0.05). Conclusion: Based on the results of the present study, self-care management behaviors have a significant effect on adaptation to chronic illness and individual characteristics affect the results. Individual assistance should be extended to the patients to develop self- care management behaviors, which can induce lifestyle changes and necessary trainings should be planned. Future research should prioritize evaluating nurse-led interdisciplinary interventions and exploring the impact of tailored strategies for specific chronic conditions to improve self-care and adaptation.Öğe Single-port laparoscopic cholecystectomy versus the classical four port laparoscopic cholecystectomy: a randomized prospective clinical trial(Edizioni Minerva Medica, 2014) Telciler, K. Emre; Ilhan, E.; Yakan, S.; Cengiz, F.; Senlikci, A.; Hayat, E. AkturkAim. The objectives of this prospective study were to compare the advantages of singleport laparoscopic cholecystectomy (SPLC) versus the classical four-port laparoscopic cholecystectomy (CLC) and to discuss these advantages in the light of current literature. Methods. Forty eligible patients were randomized to receive SPLC (Group A, N.=20) and CLC (Group B, N.=20), and investigated with regard to age, sex, BMI (body mass index), ASA (American Society of Anesthesiologists) score, type of surgery, operative time, per-operative complication, indication for conversion to open surgery, indication for additional trocar placement in SPLC technique, post-operative pain score, additional narcotic analgesic requirement, nausea and vomiting, post-operative complication and length of hospital stay. Visual analogue scale (VAS) was used for pain scoring in all cases. Results. No significant difference was found among patients in Group A and Group B in terms of age, sex, weight/BMI, ASA score, VAS scores, additional analgesic requirement and length of hospital stay (P > 0.05). On the other hand, mean operative time in Group A was significantly (P < 0.005) greater than that in Group B. Mean operative time in Group A was observed to be reduced after the first 10 operations. Conversion to open surgery was not required in any of the patients; however, additional trocar placement was required in two patients in Group A due to body habitus and adhesions, and operations were completed laparoscopically. Conclusion. We conclude that SPLC is equally effective as CLC. Patient comfort is increased and pain is decreased as the surgeon gets experienced with the technique.Öğe First-episode Mania With Psychotic Features Induced by Over-the-counter Diet Aids Containing Sibutramine(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2010) Binbay, Tolga[No abstract available]Öğe Synthesis and Characterization of Novel Organocobaloximes as Potential Catecholase and Antimicrobial Activity Agents(Wiley-V C H Verlag Gmbh, 2013) Erdem-Tuncmen, Mukadder; Karipcin, Fatma; Sariboga, BahtiyarAn asymmetric, potentially bidentate dioxime ligand (H2L) was formed by condensation of 4-biphenylchloroglyoxime and napthyl-1-amine. Two equivalents of H2L were reacted with CoCl(2)6H(2)O under appropriate conditions with deprotonation of the dioxime ligand. A series of new organocobaloxime derivatives of the type [CoR(HL)(2)Py], [CoRL2PyB2F4], and [CoRL2Py(Cu(phen))(2)] (H2L=4-(napthyl-1-amino)biphenylglyoxime; phen=1,10-phenathroline; R=izopropyl and benzyl; Py=pyridine) were synthesized. The products were characterized by elemental analysis, molar conductance, FT-IR, H-1 NMR, and magnetic susceptibility measurements. Catecholase-like activity properties of all complexes were also studied. All complexes are catalysts for the oxidation of 3,5-di-tert-butylcatechol to 3,5-di-tert-butyl-1,2-benzoquinone in methanol. Antimicrobial activity studies of H2L and the six complexes were carried out on standard strains (human pathogenic) of bacteria (Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Bacillus cereus, Enterococcus faecalis, Streptococcus pneumoniae, Listeria monocytogenes, Bacillus subtilis, Escherichia coli, Pseudominas aeruginosa, Salmonella typhi) and the yeast Candida albicans. The compounds showed a significant inhibition of the growth of the Gram-positive bacteria tested. Among the tested microorganisms, S. aureus was the most sensitive strain, especially to H2L and its complexes.Öğe Y Synthesis, characterization, and in vitro effect of the Cu(II) complex with niflumic acid and 3-picoline on paraoxanase-I(Wiley-V C H Verlag Gmbh, 2019) Dilek, Esra; Caglar, Sema; Cardak, Seda; Karakoc, Baris; Caglar, Bulent; Sahin, OnurNiflumic acid is used to treat inflammatory rheumatoid diseases, pain, and fever. The present study reports the experimental, spectroscopic, thermal, structural analyses, and biological activities of this complex. The nonsteroidal anti-inflammatory drug niflumic acid, 3-picoline, and copper(II) chloride were utilized to synthesize a new complex: [Cu2Cl2(nif)(2)(3-pic)(4)]. The crystal structure of [Cu2Cl2(nif)(2)(3-pic)(4)] was determined by X-ray crystallography. The complex crystallizes in the triclinic space group P-1 and each Cu(II) center displayed six-coordinated distorted octahedral geometry. Two Cu(II) centers are connected by a chloro-bridge to form the binuclear metal core. Finally, the in vitro effects of the synthesized new complex and free niflumic acid were evaluated on the human serum paraoxonase 1 enzyme. At low doses, both the new complex and free niflumic acid showed very good inhibition activity with different inhibition mechanisms. In addition, the results showed that the new complex has more inhibition activity than free niflumic acid.Öğe The effect of transcutaneous auricular vagus nerve stimulation on cycling ergometry and recovery in healthy young individuals(Wiley, 2023) Hatik, Sefa Haktan; Asrlan, Mesut; Demirbilek, Omer; Ozden, Ali VeyselBackground: It is aimed to examine the potential benefits and effects of the use of transcutaneous auricular vagus nerve stimulation (VNS) for sporting purposes on recovery, fatigue, and sportive performance level. Methods: In this study, 90 people between the ages of 18-23 were participated. They were randomly divided into three groups as bilateral sham, unilateral left, and bilateral VNS. A 4-day protocol was applied to the participants. Cycling exercise was performed with maximum performance for 30 min under the same watt load. Pulse, systolic and diastolic blood pressure, distance, pain, fatigue, lactic acid level, and autonomic nervous system were evaluated. Results: Within the groups, there was a statistically significant difference between the data (p < .05) except for the distance covered parameter. When we compare the groups, in addition to the distance traveled in all groups, there is no statistically significant difference in the 1st day 1st measurement and 2nd measurement data of all parameters (p > .05 When we compared the data according to days, there was a statistically significant difference between bilateral stimulation (BS) and unilateral stimulation, only pain and fatigue levels (p < .05). Conclusion: In our study, we saw that BS application gave positive results in reducing pain and fatigue due to cycling exercise compared to other applications. Similar results were obtained when we evaluated the data on a daily basis. We believe that VNS will be beneficial in reducing pain and fatigue, especially during and after the competition halftime.
