Y Synthesis, characterization, and in vitro effect of the Cu(II) complex with niflumic acid and 3-picoline on paraoxanase-I
[ X ]
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-V C H Verlag Gmbh
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Niflumic acid is used to treat inflammatory rheumatoid diseases, pain, and fever. The present study reports the experimental, spectroscopic, thermal, structural analyses, and biological activities of this complex. The nonsteroidal anti-inflammatory drug niflumic acid, 3-picoline, and copper(II) chloride were utilized to synthesize a new complex: [Cu2Cl2(nif)(2)(3-pic)(4)]. The crystal structure of [Cu2Cl2(nif)(2)(3-pic)(4)] was determined by X-ray crystallography. The complex crystallizes in the triclinic space group P-1 and each Cu(II) center displayed six-coordinated distorted octahedral geometry. Two Cu(II) centers are connected by a chloro-bridge to form the binuclear metal core. Finally, the in vitro effects of the synthesized new complex and free niflumic acid were evaluated on the human serum paraoxonase 1 enzyme. At low doses, both the new complex and free niflumic acid showed very good inhibition activity with different inhibition mechanisms. In addition, the results showed that the new complex has more inhibition activity than free niflumic acid.
Description
Keywords
copper(II) complex, crystal structure, enzyme inhibition, niflumic acid, paraoxonase 1
Journal or Series
Archiv Der Pharmazie
WoS Q Value
Q1
Scopus Q Value
Q1
Volume
352
Issue
6
