Lack of association between MAOA-uVNTR variants and excessive daytime sleepiness

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dc.contributor.authorOzen, Filiz
dc.contributor.authorYegin, Zeynep
dc.contributor.authorYavlal, Figen
dc.contributor.authorSaglam, Zuhal Aydan
dc.contributor.authorKoc, Haydar
dc.contributor.authorBerber, Ismet
dc.date.accessioned2025-03-23T19:44:32Z
dc.date.available2025-03-23T19:44:32Z
dc.date.issued2017
dc.departmentSinop Üniversitesi
dc.description.abstractSleep disorders are highly prevalent in the population and have dramatic health, social, and economic impacts. However, their treatments may remain symptomatic due to ignorance of molecular factors which may provide fundamental insights into the neurological bases of sleep. Excessive daytime sleepiness (EDS) is a common complaint encountered in neurological practice with significant effects both on individuals and on society. We aimed to investigate the role of monoamine oxidase A (MAOA) as a candidate gene in EDS. Epworth sleepiness scale (ESS) was applied to 221 subjects who were also genotyped for MAOA upstream variable number of tandem repeats (MAOA-uVNTR). Patient group displayed higher ESS values (mean 12.67) when compared with the control group (mean 6.38). However, MAOA-uVNTR genotypes did not show a significant association with ESS scores neither on women nor on men. Finally, these data suggest further replications in different populations. Moreover, the investigation of some other genes together with MAOA and/or some possible regulatory molecular mechanisms may offer a more comprehensive approach in the role of genetic factors contributing to EDS.
dc.description.sponsorshipSinop University Research Foundation [SU:SUB-1901.14-02]
dc.description.sponsorshipThis study was supported by Sinop University Research Foundation (Project No. SU:SUB-1901.14-02). The authors acknowledge Sinop University, Scientific and Technological Research Application and Research Center (SUBITAM) for scientific collaboration. The authors dedicated this article to the precious memory of Professor Dr. Ismet BERBER.
dc.identifier.doi10.1007/s10072-017-2836-6
dc.identifier.endpage774
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue5
dc.identifier.pmid28181067
dc.identifier.scopus2-s2.0-85011891005
dc.identifier.scopusqualityQ1
dc.identifier.startpage769
dc.identifier.urihttps://doi.org/10.1007/s10072-017-2836-6
dc.identifier.urihttps://hdl.handle.net/11486/6962
dc.identifier.volume38
dc.identifier.wosWOS:000402003400007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer-Verlag Italia Srl
dc.relation.ispartofNeurological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectMonoamine oxidase A
dc.subjectMAOA-uVNTR
dc.subjectSleep
dc.subjectNeurogenetics
dc.subjectExcessive daytime sleepiness
dc.subjectVariable number tandem repeat
dc.titleLack of association between MAOA-uVNTR variants and excessive daytime sleepiness
dc.typeArticle

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