Lack of association between MAOA-uVNTR variants and excessive daytime sleepiness
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer-Verlag Italia Srl
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Sleep disorders are highly prevalent in the population and have dramatic health, social, and economic impacts. However, their treatments may remain symptomatic due to ignorance of molecular factors which may provide fundamental insights into the neurological bases of sleep. Excessive daytime sleepiness (EDS) is a common complaint encountered in neurological practice with significant effects both on individuals and on society. We aimed to investigate the role of monoamine oxidase A (MAOA) as a candidate gene in EDS. Epworth sleepiness scale (ESS) was applied to 221 subjects who were also genotyped for MAOA upstream variable number of tandem repeats (MAOA-uVNTR). Patient group displayed higher ESS values (mean 12.67) when compared with the control group (mean 6.38). However, MAOA-uVNTR genotypes did not show a significant association with ESS scores neither on women nor on men. Finally, these data suggest further replications in different populations. Moreover, the investigation of some other genes together with MAOA and/or some possible regulatory molecular mechanisms may offer a more comprehensive approach in the role of genetic factors contributing to EDS.
Açıklama
Anahtar Kelimeler
Monoamine oxidase A, MAOA-uVNTR, Sleep, Neurogenetics, Excessive daytime sleepiness, Variable number tandem repeat
Kaynak
Neurological Sciences
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
38
Sayı
5
