Synthesis of axially disubstituted silicon phthalocyanines and investigation of photodynamic effects on HCT-116 colorectal cancer cell line

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dc.authoridBayrak, Riza/0000-0002-0398-7694
dc.authoridSARI, CEREN/0000-0002-5387-9851
dc.authoridDegirmencioglu, Ismail/0000-0002-7964-0427
dc.contributor.authorSari, Ceren
dc.contributor.authorEyupoglu, Figen Celep
dc.contributor.authorDegirmencioglu, Ismail
dc.contributor.authorBayrak, Riza
dc.date.accessioned2025-03-23T19:39:09Z
dc.date.available2025-03-23T19:39:09Z
dc.date.issued2018
dc.departmentSinop Üniversitesi
dc.description.abstractPhotodynamic therapy is one of the hot topics in cancer studies. Photosensitizing chemical substrates are stimulated by light having a specific wavelength to cause fatal effect on different kinds of targets. In this study, axially 4-{[(1E)-2-furylmethylene]aminol}phenol, 4-{[(1E)-2-thienylmethylene]aminol}phenol and 4-{[(1E)-(4-nitro-2-thienyl)methylene]amino}phenol disubstituted silicon phthalocyanines were synthesized as Photosensitizers for photodynamic therapy in cancer treatment. The structural characterizations of these novel compounds were performed by a combination of FT-IR, H-1-NMR, UV-vis and mass. All these newly prepared compounds did not show aggregation at the concentration range of 2 x 10(-6) - 12 x 10(-6) M in tetrahydrofurane and also did not show aggregation in different organic solvents at 2 x 10(-6) M concentration. Phthalocyanines synthesized in this study were tested on HCT-116 colorectal cancer cells and stimulated by light has wavelength of 680 nm. The toxic effects on cancer cells which are caused by different concentrations of photosensitizing molecules have been examined and compared with the toxic effects on cancer cells that were kept in the dark. It is confirmed that these molecules caused toxic effects on colorectal cancer cells when they were stimulated by light but there was no toxic effect in the dark.
dc.description.sponsorshipKTU Scientific Research Council [FAY-2015-5342]
dc.description.sponsorshipThe authors thank the KTU Scientific Research Council. (Project Number: FAY-2015-5342) for funding.
dc.identifier.doi10.1016/j.pdpdt.2018.05.009
dc.identifier.endpage88
dc.identifier.issn1572-1000
dc.identifier.issn1873-1597
dc.identifier.pmid29775760
dc.identifier.scopus2-s2.0-85048538137
dc.identifier.scopusqualityQ1
dc.identifier.startpage83
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2018.05.009
dc.identifier.urihttps://hdl.handle.net/11486/6266
dc.identifier.volume23
dc.identifier.wosWOS:000446285400018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectSilicon phthalocyanine
dc.subjectSynthesis
dc.subjectHCT-116
dc.subjectColorectal cancer
dc.subjectPhotodynamic therapy
dc.titleSynthesis of axially disubstituted silicon phthalocyanines and investigation of photodynamic effects on HCT-116 colorectal cancer cell line
dc.typeArticle

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