Synthesis of axially disubstituted silicon phthalocyanines and investigation of photodynamic effects on HCT-116 colorectal cancer cell line
[ X ]
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Photodynamic therapy is one of the hot topics in cancer studies. Photosensitizing chemical substrates are stimulated by light having a specific wavelength to cause fatal effect on different kinds of targets. In this study, axially 4-{[(1E)-2-furylmethylene]aminol}phenol, 4-{[(1E)-2-thienylmethylene]aminol}phenol and 4-{[(1E)-(4-nitro-2-thienyl)methylene]amino}phenol disubstituted silicon phthalocyanines were synthesized as Photosensitizers for photodynamic therapy in cancer treatment. The structural characterizations of these novel compounds were performed by a combination of FT-IR, H-1-NMR, UV-vis and mass. All these newly prepared compounds did not show aggregation at the concentration range of 2 x 10(-6) - 12 x 10(-6) M in tetrahydrofurane and also did not show aggregation in different organic solvents at 2 x 10(-6) M concentration. Phthalocyanines synthesized in this study were tested on HCT-116 colorectal cancer cells and stimulated by light has wavelength of 680 nm. The toxic effects on cancer cells which are caused by different concentrations of photosensitizing molecules have been examined and compared with the toxic effects on cancer cells that were kept in the dark. It is confirmed that these molecules caused toxic effects on colorectal cancer cells when they were stimulated by light but there was no toxic effect in the dark.
Açıklama
Anahtar Kelimeler
Silicon phthalocyanine, Synthesis, HCT-116, Colorectal cancer, Photodynamic therapy
Kaynak
Photodiagnosis and Photodynamic Therapy
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
23
