A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection

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dc.authoridGokcay Bek, Sibel/0000-0003-3325-5993
dc.contributor.authorDincer, Mevlut Tamer
dc.contributor.authorEren, Necmi
dc.contributor.authorMurt, Ahmet
dc.contributor.authorYildiz, Nuriye
dc.contributor.authorOzcan, Seyda Gul
dc.contributor.authorErgul, Metin
dc.contributor.authorBek, Sibel Gokcay
dc.date.accessioned2025-03-23T19:25:35Z
dc.date.available2025-03-23T19:25:35Z
dc.date.issued2022
dc.departmentSinop Üniversitesi
dc.description.abstractBackground/aim: Data on antibody response following COVID-19 in kidney transplant recipients is scarce. This crosssectional study aims to investigate the antibody response to COVID-19 among kidney transplant recipients. Materials and methods: We recruited 46 kidney transplant recipients with RT-PCR-confirmed COVID-19 and 45 recipients without COVID-19 history. We also constructed two control groups (COVID-19 positive and negative) from a historical cohort of healthcare workers. We used age and sex-based propensity score matching to select the eligible subjects to the control groups. We measured the SARS-CoV-2 IgG levels quantitatively using the Abbott ARCHITECT system. An antibody level above 1.4 S/C was defined as positivity. Results: Transplant recipients with COVID-19 had a higher BMI, and COVID-19 history in a household member was more common than that of the transplant recipient without COVID-19. IgG seropositivity rate (69.6% vs. 78.3%, p = 0.238) and the median IgG level (3.28 [IQR: 0.80-5.85] vs. 4.59 [IQR: 1.61-6.06], p = 0.499) were similar in COVID-19-positive transplant recipients and controls. Kidney transplant recipients who had a longer duration between RT-PCR and antibody testing had lower antibody levels (r = -0.532, p < 0.001). Conclusion: At the early post-COVID-19 period, kidney transplant recipients have a similar antibody response to controls. However, these patients' antibody levels and immunity should be closely monitored in the long term.
dc.description.sponsorshipIstanbul branch of Turkish Society of Nephrology [2711_2020]
dc.description.sponsorshipThis present work was supported by the Istanbul branch of Turkish Society of Nephrology (grant number: 2711_2020).
dc.identifier.doi10.55730/1300-0144.5520
dc.identifier.endpage1761
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid36945967
dc.identifier.scopus2-s2.0-85144551579
dc.identifier.scopusqualityQ1
dc.identifier.startpage1754
dc.identifier.trdizinid1145489
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5520
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1145489
dc.identifier.urihttps://hdl.handle.net/11486/4514
dc.identifier.volume52
dc.identifier.wosWOS:000906716200002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectCOVID-19
dc.subjectimmune response
dc.subjectimmunosuppression
dc.subjectkidney transplantation
dc.subjectSARS-CoV-2 IgG antibody
dc.titleA comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection
dc.typeArticle

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