A porous molecularly imprinted nanofilm for selective and sensitive sensing of an anticancer drug ruxolitinib

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dc.authoridCetinkaya, Ahmet/0000-0001-5014-0907
dc.authoridOZKAN, Sibel/0000-0001-7494-3077
dc.authoridBellur Atici, Esen/0000-0002-4093-441X
dc.authoridOzcelikay, Goksu/0000-0001-7919-3236
dc.authoridCorman, Mehmet Emin/0000-0001-9062-4201
dc.authoridUzun, Lokman/0000-0002-3971-7725
dc.contributor.authorcorman, M. Emin
dc.contributor.authorCetinkaya, Ahmet
dc.contributor.authorOzcelikay, Goksu
dc.contributor.authorOzgur, Erdogan
dc.contributor.authorAtici, Esen B.
dc.contributor.authorUzun, Lokman
dc.contributor.authorOzkan, Sibel A.
dc.date.accessioned2025-03-23T19:42:11Z
dc.date.available2025-03-23T19:42:11Z
dc.date.issued2021
dc.departmentSinop Üniversitesi
dc.description.abstractA novel methodology has been applied to generate a porous molecularly imprinted material for highly selective and sensitive recognition of Janus kinase inhibitor ruxolitinib (RUX). The porous material-based nucleobase-derivative functional monomer was developed by a photopolymerization method. The thymine methacrylate (ThyM) as a functional monomer was synthesized and copolymerized with 2hydroxyethyl methacrylate (HEMA) in the presence of ethylene glycol dimethacrylate (EGDMA) onto the glassy carbon electrode [glassy carbon electrode/molecularly imprinted polymer@poly(2hydroxyethyl methacrylate-co-thymine methacrylate), (GCE/MIP@PHEMA-ThyM)] for the first time. The presence of ThyM results in the functional groups in imprinting binding sites, while the presence of poly(vinyl alcohol) (PVA) allows to generate porous materials for sensitive sensing. The characterization of GCE/MIP@PHEMA-ThyM was investigated by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), and impedance spectroscopy technique. Then, the porous MIP modified glassy carbon electrode was optimized with effecting parameters including removal agent, removal time, and incubation time to get a better response for RUX. Under well-controlled optimum conditions, the GCE/MIP@PHEMA-ThyM linearly responded to the RUX concentration up to 0.01 pM at the limit of detection (LOD) of 0.00191 pM. The non-imprinted polymer (NIP) was also prepared to serve as a control in the same way but without the template. The proposed method improves the accessibility of binding sites by generating the porous material resulting in highly selective and sensitive recognition of drugs in the pharmaceutical dosage form and synthetic human serum samples. (c) 2021 Elsevier B.V. All rights reserved.
dc.description.sponsorshipCorman thanks the Scientific and Technological Research Council of Turkey (TUBITAK) under the BIDEB/2218-National Postdoctoral Research Fellowship Program for Turkish Citizens; Council of Higher Education 100/2000 (YOK) under the special 100/2000 Programme; Scientific and Technological Research Council of Turkey (TUBITAK) under the BIDEB/2211-A Ph.D. Scholarship Programme
dc.description.sponsorshipMehmet Emin Corman thanks the Scientific and Technological Research Council of Turkey (TUBITAK) under the BIDEB/2218-National Postdoctoral Research Fellowship Program for Turkish Citizens. Ahmet Cetinkaya thanks the financial supports from the Council of Higher Education 100/2000 (YOK) under the special 100/2000 and the Scientific and Technological Research Council of Turkey (TUBITAK) under the BIDEB/2211-A Ph.D. Scholarship Programmes.
dc.identifier.doi10.1016/j.aca.2021.339143
dc.identifier.issn0003-2670
dc.identifier.issn1873-4324
dc.identifier.pmid34753569
dc.identifier.scopus2-s2.0-85116914096
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.aca.2021.339143
dc.identifier.urihttps://hdl.handle.net/11486/6723
dc.identifier.volume1187
dc.identifier.wosWOS:000724683500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofAnalytica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectRuxolitinib
dc.subjectMolecularly imprinted polymer
dc.subjectPhotopolymerization
dc.subjectVoltammetry
dc.subjectDrug analysis
dc.titleA porous molecularly imprinted nanofilm for selective and sensitive sensing of an anticancer drug ruxolitinib
dc.typeArticle

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