A medical and molecular approach to kefir as a therapeutic agent of human microbiota A review

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dc.contributor.authorYegin, Zeynep
dc.contributor.authorSudagidan, Mert
dc.date.accessioned2025-03-23T19:35:48Z
dc.date.available2025-03-23T19:35:48Z
dc.date.issued2024
dc.departmentSinop Üniversitesi
dc.description.abstractThe imbalanced microbial composition called as dysbiosis constitutes a tendency related to different kind of human diseases. To overcome the disadvantages of dysbiosis, the consumption of probiotics is an emerging and promising topic of the last decade. Kefir is a probiotic fermented beverage produced from the fermentation of kefir grains with changing varieties of milk and displays a symbiotic association of bacteria and yeast. The discovery of the concept that fermented foods/beverages such as kefir could modify gut microbiota in humans has widened the borders of precision medicine and now microbiome therapeutics can be considered as a significant part of this field. Kefir seems to have potential to guide and manipulate future replacement/complementary therapies with a variety of beneficial biological/medical properties it has. The aim of this review was a comprehensive recapitulation of probiotic beverage kefir's significant properties mainly focusing of antioxidative, immunomodulatory, apoptotic, antitumor, neuroprotective. Apoptotic/antimetastatic effects are regulated at the molecular level by increases in TGF-beta 1, caspase-3, p53, Bax, Bax:Bcl-2 ratio, p21 and decreases in TGF-alpha, Bcl-2 and MMP polarization. Neuroprotective effects are revealed upon upregulation of SOD/catalase and anti-inflammatory Treg cells, decreases in repetitive behavior and modulation of apoptotic genes. Besides these significant features that may offer quite advantages in supplementary cancer therapies, the scope was also extended to recent emerging medical topics and also discussed and evaluated the concept of psychobiotics. The therapeutic potential of psychobiotic effect is majorly attributed to the increased ratios of Clostridium butyricum, Lactobacillus and Bifidobacterium.
dc.identifier.doi10.1024/0300-9831/a000765
dc.identifier.endpage80
dc.identifier.issn0300-9831
dc.identifier.issn1664-2821
dc.identifier.issue1
dc.identifier.pmid36068959
dc.identifier.scopus2-s2.0-85139061186
dc.identifier.scopusqualityQ2
dc.identifier.startpage71
dc.identifier.urihttps://doi.org/10.1024/0300-9831/a000765
dc.identifier.urihttps://hdl.handle.net/11486/5936
dc.identifier.volume94
dc.identifier.wosWOS:000850427000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherImr Press
dc.relation.ispartofInternational Journal For Vitamin and Nutrition Research
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectKefir
dc.subjectprobiotic
dc.subjectmicrobiota
dc.subjectapoptosis
dc.subjectantitumor
dc.subjectneuroprotection
dc.subjectpsychobiotic
dc.titleA medical and molecular approach to kefir as a therapeutic agent of human microbiota A review
dc.typeReview

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