A medical and molecular approach to kefir as a therapeutic agent of human microbiota A review
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Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Imr Press
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The imbalanced microbial composition called as dysbiosis constitutes a tendency related to different kind of human diseases. To overcome the disadvantages of dysbiosis, the consumption of probiotics is an emerging and promising topic of the last decade. Kefir is a probiotic fermented beverage produced from the fermentation of kefir grains with changing varieties of milk and displays a symbiotic association of bacteria and yeast. The discovery of the concept that fermented foods/beverages such as kefir could modify gut microbiota in humans has widened the borders of precision medicine and now microbiome therapeutics can be considered as a significant part of this field. Kefir seems to have potential to guide and manipulate future replacement/complementary therapies with a variety of beneficial biological/medical properties it has. The aim of this review was a comprehensive recapitulation of probiotic beverage kefir's significant properties mainly focusing of antioxidative, immunomodulatory, apoptotic, antitumor, neuroprotective. Apoptotic/antimetastatic effects are regulated at the molecular level by increases in TGF-beta 1, caspase-3, p53, Bax, Bax:Bcl-2 ratio, p21 and decreases in TGF-alpha, Bcl-2 and MMP polarization. Neuroprotective effects are revealed upon upregulation of SOD/catalase and anti-inflammatory Treg cells, decreases in repetitive behavior and modulation of apoptotic genes. Besides these significant features that may offer quite advantages in supplementary cancer therapies, the scope was also extended to recent emerging medical topics and also discussed and evaluated the concept of psychobiotics. The therapeutic potential of psychobiotic effect is majorly attributed to the increased ratios of Clostridium butyricum, Lactobacillus and Bifidobacterium.
Açıklama
Anahtar Kelimeler
Kefir, probiotic, microbiota, apoptosis, antitumor, neuroprotection, psychobiotic
Kaynak
International Journal For Vitamin and Nutrition Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
94
Sayı
1
