Association analysis of Epworth Sleepiness Scale (ESS) scores with serotonin transporter (5-HTT- LPR, 5-HTT-VNTR) and circadian (PER3-VNTR) genes

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dc.contributor.authorOzen, Filiz
dc.contributor.authorYegin, Zeynep
dc.contributor.authorSaglam, Zuhal Aydan
dc.contributor.authorYavlal, Figen
dc.contributor.authorKoc, Haydar
dc.contributor.authorUlasoglu, Celal
dc.date.accessioned2025-03-23T19:25:32Z
dc.date.available2025-03-23T19:25:32Z
dc.date.issued2022
dc.departmentSinop Üniversitesi
dc.description.abstractExcessive daytime sleepiness (EDS) is a common complaint encountered in clinical practice with serious consequences both for individual and society since it can increase the ratio of motor vehicle accidents, work-related incidents, and deaths. Moreover, it also manifests less serious individual consequences. This study aimed to investigate the potential role of PER3-VNTR, 5-HTT-LPR, and 5-HTT-VNTR in terms of constituting liability to EDS. Two hundred eighteen participants (93 complaining about daytime sleepiness and 125 individuals with no serious complaint) were recruited in the study. General daytime of sleepiness was quantified with Epworth sleepiness scale (ESS). DNA extractions were performed from collected blood samples with standart salting-out procedure and genotyped. ESS scores displayed difference between individuals suffering from sleep disturbances and other individuals with values of 12.75 +/- 4.55 and 6.34 +/- 4.26, respectively. PER3VNTR and 5-HTT-LPR genotypes did not display association with mean ESS scores. However, 5-HTT-VNTR genotypes showed significant association with mean ESS scores; individuals with 10/10 genotypes had the highest ESS score reflecting this genotype as a liability factor for EDS. We strongly recommend further studies based on circadian/serotonin pathway genes in different populations to reach to a consensus and highlight sleep genetic marker genes which then can be the future targets of pharmacological treatment studies for sleep problems.
dc.identifier.doi10.5935/1984-0063.20220003
dc.identifier.endpage115
dc.identifier.issn1984-0659
dc.identifier.issn1984-0063
dc.identifier.pmid35273755
dc.identifier.scopus2-s2.0-85125642792
dc.identifier.scopusqualityQ2
dc.identifier.startpage110
dc.identifier.urihttps://doi.org/10.5935/1984-0063.20220003
dc.identifier.urihttps://hdl.handle.net/11486/4493
dc.identifier.volume15
dc.identifier.wosWOS:000757237000009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherThieme Medical Publ Inc
dc.relation.ispartofSleep Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectNeurogenetics
dc.subjectExcessive daytime sleepiness (EDS)
dc.subjectEpworth Sleepiness Scale (ESS)
dc.subjectPER3
dc.subjectSerotonin transporter (5-HTT)
dc.subjectGenetic association
dc.titleAssociation analysis of Epworth Sleepiness Scale (ESS) scores with serotonin transporter (5-HTT- LPR, 5-HTT-VNTR) and circadian (PER3-VNTR) genes
dc.typeArticle

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