The effect of Plantago major Linnaeus on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals after administration of 7,12-dimethylbenz(a)anthracene in rats

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dc.authoridOzdemir, Hulya/0000-0002-6045-8342
dc.authoridLevent, Abdulkadir/0000-0001-5792-419X
dc.authoridEkin, Suat/0000-0002-6502-5028
dc.contributor.authorOto, Gokhan
dc.contributor.authorEkin, Suat
dc.contributor.authorOzdemir, Hulya
dc.contributor.authorLevent, Abdulkadir
dc.contributor.authorBerber, Ismet
dc.date.accessioned2025-03-23T19:30:44Z
dc.date.available2025-03-23T19:30:44Z
dc.date.issued2012
dc.departmentSinop Üniversitesi
dc.description.abstractThe present study was designed to evaluate the effect of Plantago major Linnaeus (PM) extract on serum total sialic acid (TSA), lipid-bound sialic acid (LSA), some trace elements (copper (Cu), zinc (Zn) and iron) and mineral levels (magnesium, calcium and sodium) in Wistar albino rat administrated 7,12-dimethylbenz(a)anthracene (DMBA). Rats were divided into three equal groups (n = 6). Group I comprised the control group, group II was treated with DMBA (100 mg/kg, single dose) and group III was treated with DMBA (100 mg/kg single dose) and aqueous extract of PM 100 mg/kg/day for 60 days. After 60 days, statistical analyses showed that TSA and LSA levels in DMBA and DMBA + PM groups were significantly higher compared to the control group (TSA: p < 0.01, p < 0.05; LSA: p < 0.05, p < 0.05, respectively). Serum Zn levels were decreased in subjects treated with DMBA (p < 0.01) and DMBA + PM (p < 0.05) compared to the control group values. Serum Cu levels were increased in DMBA group and PM-treated group compared to the control group values. The results of this investigation showed that the levels of TSA and LSA changed significantly, which are sensitive markers for detecting the toxic effects of DMBA. On the other hand, observed decline in Zn levels in rats from DMBA + PM group might be due to decreased generation of free radicals and oxidative stress. Results from this study suggest that PM may be partially effective in preventing carcinogenesis initiated by environmental carcinogen DMBA.
dc.description.sponsorshipScientific Research Projects Presidency of Yuzuncu Yil University [2008-FED-B083]
dc.description.sponsorshipThis study was supported by a grant from the Scientific Research Projects Presidency of Yuzuncu Yil University (2008-FED-B083).
dc.identifier.doi10.1177/0748233711412422
dc.identifier.endpage342
dc.identifier.issn0748-2337
dc.identifier.issue4
dc.identifier.pmid21996710
dc.identifier.scopus2-s2.0-84861796540
dc.identifier.scopusqualityQ2
dc.identifier.startpage334
dc.identifier.urihttps://doi.org/10.1177/0748233711412422
dc.identifier.urihttps://hdl.handle.net/11486/5154
dc.identifier.volume28
dc.identifier.wosWOS:000302628600006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectDMBA
dc.subjectPlantago major L
dc.subjectTSA
dc.subjectLSA
dc.subjecttrace elements
dc.titleThe effect of Plantago major Linnaeus on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals after administration of 7,12-dimethylbenz(a)anthracene in rats
dc.typeArticle

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