Biochemical Effects of Long-Term Exercise on Oxidative Stress and Antioxidant Markers in Adolescent Female Athletes

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dc.contributor.authorBilici, Omer Faruk
dc.contributor.authorErkan, Dilara
dc.contributor.authorAlexe, Dan Iulian
dc.contributor.authorTohanean, Dragos Ioan
dc.contributor.authorDemir, Canan
dc.contributor.authorAlexe, Cristina Ioana
dc.contributor.authorVoiculescu, Virgil Ene
dc.date.accessioned2026-04-25T14:20:27Z
dc.date.available2026-04-25T14:20:27Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractBackground: Adolescence is a critical period where exercise-induced oxidative stress is modulated by both training adaptations and hormonal changes, particularly the antioxidant effects of estrogen in females. However, data on how adolescent female athletes respond to long-term exercise remain limited. The aim of this study was to examine oxidative stress levels and some antioxidant defense parameters in adolescent female athletes who train regularly. Methods: The study included 20 adolescent female basketball players (16.65 +/- 0.67 years; 165.50 +/- 0.06 cm; 59.75 +/- 5.50 kg) with at least three years of training experience and 20 non-athlete adolescent female participants (16.80 +/- 0.69 years; 159.95 +/- 0.04 cm; 60.15 +/- 4.23 kg). Malondialdehyde (MDA), glutathione (GSH), and catalase (CAT) levels were analyzed by a spectrophotometric method using a UV/VIS spectrophotometer in blood samples taken from all participants, and the data were compared between the groups. Results: The results showed that MDA levels were significantly lower in the athlete group (p < 0.01; d = 4.78). In addition, CAT activity was significantly higher in athletes compared to non-athletes (p < 0.01; d = 7.81). However, no significant difference was observed in GSH levels between the groups (p > 0.05; d = 0.15). A strong negative correlation was found between MDA and CAT (r = -0.900). Conclusions: These findings suggest that prolonged exercise reduces oxidative stress and enhances catalase-mediated antioxidant defense in adolescent women. Increased CAT activity and decreased MDA levels support this effect, while stable GSH levels point to the role of compensatory mechanisms.
dc.identifier.doi10.3390/children12070809
dc.identifier.issn2227-9067
dc.identifier.issue7
dc.identifier.orcid0000-0002-4204-9756
dc.identifier.orcid0000-0003-0774-0848
dc.identifier.orcid0000-0001-7424-7741
dc.identifier.orcid0000-0001-7767-8416
dc.identifier.orcid0000-0002-2403-4841
dc.identifier.orcid0000-0002-6740-1867
dc.identifier.orcid0000-0002-6396-761X
dc.identifier.pmid40723002
dc.identifier.scopus2-s2.0-105011488121
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/children12070809
dc.identifier.urihttps://hdl.handle.net/11486/8582
dc.identifier.volume12
dc.identifier.wosWOS:001540949900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofChildren-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260420
dc.subjectoxidative stress
dc.subjectantioxidants
dc.subjectadolescent
dc.subjectfemale
dc.subjectathletes
dc.subjectexercise
dc.titleBiochemical Effects of Long-Term Exercise on Oxidative Stress and Antioxidant Markers in Adolescent Female Athletes
dc.typeArticle

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