Synthesis and characterization of four novel palladium(II) and platinum(II) complexes with 1-(2-aminoethyl)pyrrolidine, diclofenac and mefenamic acid: In vitro effect of these complexes on human serum paraoxanase1 activity

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dc.authoridDilek, Esra/0000-0002-3629-5168
dc.contributor.authorDilek, Esra
dc.contributor.authorCaglar, Sema
dc.contributor.authorErdogan, Kuebra
dc.contributor.authorCaglar, Bulent
dc.contributor.authorSahin, Onur
dc.date.accessioned2025-03-23T19:47:10Z
dc.date.available2025-03-23T19:47:10Z
dc.date.issued2018
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, the effects of four novel mononuclear palladium(II) and platinum(II) complexes on the activity of human serum paraoxanase1 were examined. First, four novel mononuclear palladium(II) and platinum(II) complexes were synthesized with a nitrogen donor ligand 1-(2-aminoethyl)pyrrolidine and nonsteroidal anti-inflammatory drugs diclofenac, mefenamic acid. These complexes were characterized by spectroscopic, thermal, and elemental analyses. The crystal structures of complex [Pd(2-amepyr)(2)](dicl)(2) 1 and [Pd(2-amepyr)(2)](mef)(2) 3 were determined by X-ray crystallography. Then, paraoxonase1 enzyme was purified from human serum. The effects of these complexes on enzyme were evaluated in vitro. The complexes consist of the cationic unit and the counterions. The diclofenac and mefenamic acid acted as a counterion in the complexes. It was observed that all the complexes were stable up to high temperatures. These complexes, even at low doses, inhibited the activity of the enzyme with different inhibition mechanisms.
dc.description.sponsorshipErzincan University [FEN-A-020414-0068]
dc.description.sponsorshipErzincan University, Grant/Award Number: FEN-A-020414-0068
dc.identifier.doi10.1002/jbt.22043
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue4
dc.identifier.pmid29512227
dc.identifier.scopus2-s2.0-85043341903
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.22043
dc.identifier.urihttps://hdl.handle.net/11486/7299
dc.identifier.volume32
dc.identifier.wosWOS:000430391900002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectcrystal structure
dc.subjectenzyme inhibition
dc.subjectpalladium(II) and platinum(II) complexes
dc.subjectparaoxonase1
dc.titleSynthesis and characterization of four novel palladium(II) and platinum(II) complexes with 1-(2-aminoethyl)pyrrolidine, diclofenac and mefenamic acid: In vitro effect of these complexes on human serum paraoxanase1 activity
dc.typeArticle

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