Hepatoprotective Effects of Curcumin on Liver Injury in Streptozocin-induced Diabetic Rats

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dc.contributor.authorOzkaptan, Bilge Bal
dc.contributor.authorSagir, Dilek
dc.contributor.authorAksoy, Fatma
dc.date.accessioned2025-03-23T19:26:01Z
dc.date.available2025-03-23T19:26:01Z
dc.date.issued2024
dc.departmentSinop Üniversitesi
dc.description.abstractIntroduction: Type 2 diabetes mellitus is characterized by chronically elevated blood sugar levels associated with disruption of the inflammatory and oxidative state and dyslipidemia. Curcumin is a highly pleiotropic molecule with hypoglycemic, hypolipidemic, anti-inflammatory, and antioxidant properties. The aim of this study was to evaluate the effects of curcumin on the liver of streptozotocin-induced diabetic rats. Materials and Methods: Thirty-two adult male rats were used in the study. The rats were divided into four groups: Control (C), Diabetes (D), Curcumin (CUR), and Diabetes + Curcumin (D + CUR) (n = 8). The groups given curcumin were given 60 mg/kg curcumin by gavage once a day during the 14-day study period. At the end of the experiment, biochemical, stereological, histological, and immunohistochemical analyses were performed on blood and liver samples taken from rats sacrificed. Results: After curcumin treatment in diabetic rats, there was a significant decrease in blood glucose levels, hepatic markers, and levels of thiobarbituric acid reactive substances (P < 0.01). Furthermore, a significant increase in enzymatic antioxidants such as superoxide dismutase, catalase, and glutathione peroxidase was observed after treatment (P < 0.01). It was determined that curcumin decreased the apoptotic index and the number of dual-nucleated hepatocytes in the liver, and provided support for liver regeneration (P < 0.01). Discussion and Conclusion: Based on the findings of this study, it can be concluded that curcumin has the potential to protect against hyperglycemia-induced oxidative stress and apoptosis in liver cells, and also induces regeneration in damaged liver.
dc.description.sponsorshipSinop University Scientific Research Projects Coordinatorship [SYO-1901-18-38]
dc.description.sponsorshipThis research was supported by the Sinop University Scientific Research Projects Coordinatorship (Project number: SYO-1901-18-38).
dc.identifier.doi10.4103/jasi.jasi_55_23
dc.identifier.endpage226
dc.identifier.issn0003-2778
dc.identifier.issn2352-3050
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85205305017
dc.identifier.scopusqualityQ4
dc.identifier.startpage218
dc.identifier.urihttps://doi.org/10.4103/jasi.jasi_55_23
dc.identifier.urihttps://hdl.handle.net/11486/4608
dc.identifier.volume73
dc.identifier.wosWOS:001335465600005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofJournal of the Anatomical Society of India
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectApoptosis
dc.subjectcurcumin
dc.subjectdiabetes
dc.subjectliver
dc.subjectoxidative stress
dc.titleHepatoprotective Effects of Curcumin on Liver Injury in Streptozocin-induced Diabetic Rats
dc.typeArticle

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