Hepatoprotective Effects of Curcumin on Liver Injury in Streptozocin-induced Diabetic Rats
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Date
2024
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer Medknow Publications
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Introduction: Type 2 diabetes mellitus is characterized by chronically elevated blood sugar levels associated with disruption of the inflammatory and oxidative state and dyslipidemia. Curcumin is a highly pleiotropic molecule with hypoglycemic, hypolipidemic, anti-inflammatory, and antioxidant properties. The aim of this study was to evaluate the effects of curcumin on the liver of streptozotocin-induced diabetic rats. Materials and Methods: Thirty-two adult male rats were used in the study. The rats were divided into four groups: Control (C), Diabetes (D), Curcumin (CUR), and Diabetes + Curcumin (D + CUR) (n = 8). The groups given curcumin were given 60 mg/kg curcumin by gavage once a day during the 14-day study period. At the end of the experiment, biochemical, stereological, histological, and immunohistochemical analyses were performed on blood and liver samples taken from rats sacrificed. Results: After curcumin treatment in diabetic rats, there was a significant decrease in blood glucose levels, hepatic markers, and levels of thiobarbituric acid reactive substances (P < 0.01). Furthermore, a significant increase in enzymatic antioxidants such as superoxide dismutase, catalase, and glutathione peroxidase was observed after treatment (P < 0.01). It was determined that curcumin decreased the apoptotic index and the number of dual-nucleated hepatocytes in the liver, and provided support for liver regeneration (P < 0.01). Discussion and Conclusion: Based on the findings of this study, it can be concluded that curcumin has the potential to protect against hyperglycemia-induced oxidative stress and apoptosis in liver cells, and also induces regeneration in damaged liver.
Description
Keywords
Apoptosis, curcumin, diabetes, liver, oxidative stress
Journal or Series
Journal of the Anatomical Society of India
WoS Q Value
Q4
Scopus Q Value
Q4
Volume
73
Issue
3
