Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study

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dc.authoridYILMAZ, Ali Kerim/0000-0002-0046-6711
dc.authoridGUZEL, Nizamettin/0000-0003-4765-5285
dc.authoridAkdemir, Enes/0000-0002-1000-2881
dc.authoridSaka Baraz, Lale/0000-0003-4387-6929
dc.authoridAnil, Berna/0000-0002-8070-0626
dc.authoridSANCAKLI, AYKUT/0000-0003-3611-4942
dc.authoridKorkmaz Salkilic, Esra/0000-0003-4545-210X
dc.contributor.authorGenc, Ahmet Serhat
dc.contributor.authorYilmaz, Ali Kerim
dc.contributor.authorAnil, Berna
dc.contributor.authorSalkilic, Esra Korkmaz
dc.contributor.authorAkdemir, Enes
dc.contributor.authorSancakli, Aykut
dc.contributor.authorMor, Ahmet
dc.date.accessioned2025-03-23T19:25:39Z
dc.date.available2025-03-23T19:25:39Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractObjectives: The aim of this study was to assess the effect of Naturagen (R) 4 Joint product, containing type 1, 2, and 3 collagen, on pain associated with osteoarthritis (OA) and to evaluate its effects on quality of life and physical functioning. Patients and methods: This double-blind, randomized, placebo-controlled clinical study included a total of 31 patients (8 males, 23 females; mean age: 53.5 +/- 9.1 years; range, 35 to 65 years) with Grade 2-3 OA according to the Kellgren-Lawrence (KL) classification system between June 2023 and November 2023. The patients were divided into two groups: a collagen group (n=16) and a placebo group (n=15). The Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS-PS), Oxford Knee Score (OKS), Tampa Scale for Kinesiophobia (TSK), Short Form Health Survey (SF-12), Foot Function Index (FFI), Timed Up and Go (TUG), 6-Min Walking Test (6MWT), Five Repetition Sit to Stand Test (5STS), Stair Climbing Test (SCT), and Berg Balance Scale (BBS) were used. All tests were performed before and after eight weeks of collagen supplementation. Results: Eight weeks of collagen supplementation yielded notable enhancements across all osteoarthritis-related pain and quality of life scales evaluated, including VAS, WOMAC, KOOS-PS, OKS, TSK, SF-12, and FFI scores (p<0.05). In functional evaluations, there were significant positive effects of collagen use in BBS and 6MWT results (p<0.05). In TUG, 5STS, and SCT tests, no significant difference was found between the groups (p>0.05). Conclusion: Our study results suggest that the eight-week collagen-based supplement exerts a favorable effect on pain and quality of life levels, as well as some functional test results.
dc.identifier.doi10.52312/jdrs.2025.1965
dc.identifier.endpage96
dc.identifier.issn2687-4792
dc.identifier.issue1
dc.identifier.pmid39719905
dc.identifier.scopus2-s2.0-85213920459
dc.identifier.scopusqualityQ2
dc.identifier.startpage85
dc.identifier.urihttps://doi.org/10.52312/jdrs.2025.1965
dc.identifier.urihttps://hdl.handle.net/11486/4533
dc.identifier.volume36
dc.identifier.wosWOS:001351131300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Joint Diseases Foundation
dc.relation.ispartofJoint Diseases and Related Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectCollagen supplement
dc.subjectosteoarthritis
dc.subjectpain
dc.subjectphysical function
dc.subjectquality of life
dc.titleEffect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study
dc.typeArticle

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