Synthesis, characterization and anticancer activity in vitro evaluation of novel dicyanoaurate (I)-based complexes

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dc.authoridSEN, FATIH/0000-0001-9929-9556
dc.authoridaydin, ali/0000-0002-9550-9111
dc.authoridKaradag, Ahmet/0000-0003-4676-683X
dc.contributor.authorKaradag, Ahmet
dc.contributor.authorAydin, Ali
dc.contributor.authorTekin, Saban
dc.contributor.authorAkbas, Huseyin
dc.contributor.authorSahin, Onur
dc.contributor.authorSen, Fatih
dc.date.accessioned2025-03-23T19:40:57Z
dc.date.available2025-03-23T19:40:57Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractMolecular structures containing gold, such as auranofin, have been extensively studied in the diagnosis and treatment of many diseases, including cancer treatment. The pharmacological properties of the newly synthesized unique gold-ligand structures have been reported for different cancer cell lines. However, findings on bishydeten-metal salt complexes with gold are rare. In this work, the synthesis of five novel cyanide-bridged coordination compounds having the closed formulae [Ni(bishydeten)][Au(CN)(2)](2) (1), [Cu(bishydeten)][Au (CN)(2)](2) (2), [Zn(bishydeten)(2)Au-3(CN)(4)][Au-2(CN)(3)] (3), [Cd(bishydeten)(0,5)](2)[Au(CN)(2)](4).2H(2)O (4), and [Cd(bishydeten)(2)][Au(CN)(2)](2) (5) (where bisyhdeten = N,N-bis(2-hydroxyethyl)ethylene diamine), and their characterization by elemental, infrared, ESI-MS, X-ray (for 2) and thermic measurement methods were performed. Complexes 1 and 3 are thermally more stable than the other three complexes. For these, pharmacological adequacies were also tested. The nucleic acid and protein binding affinities of the Au (I) compounds were also estimated by spectroscopic and electrophoretic techniques. Au (I) complexes were identified as strong chemotherapeutic with mild cytotoxicity, and they demonstrated a dose-dependent inhibition on the growth of cancer cells with IC50 at 0.11 to 0.47 mu M. Investigation of mechanisms of action on cells revealed that Au (I) compounds managed to inhibit cell migration and led to a decrease in cytoskeletal proteins such as CK7 and CK20. However, Au (I) compounds failed to inhibit DNA topoisomerase I. Overall, and we suggest that potent antiproliferative activity, mild cytotoxicity, good solubility, and micromolar dosage of Au (I) compounds containing bisyhdeten-metal derivatives render them the potential focus of further studies as chemotherapeutic agents.
dc.description.sponsorshipTechnical Research Council and Scientific of Turkey (TUBITAK, COST Action) [CM 2515, TBAG-112T696]
dc.description.sponsorshipThe authors of this study would like to thank the financial support of the Technical Research Council and Scientific of Turkey (TUBITAK, COST Action CM 2515; Grant no: TBAG-112T696).
dc.identifier.doi10.1016/j.lfs.2020.117635
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.pmid32272179
dc.identifier.scopus2-s2.0-85083112313
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2020.117635
dc.identifier.urihttps://hdl.handle.net/11486/6469
dc.identifier.volume251
dc.identifier.wosWOS:000530719800007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofLife Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectAntiproliferative effect
dc.subjectCrystal structure
dc.subjectCytotoxicity
dc.subjectDicyanoaurate (I)
dc.subjectSpectroscopic titration
dc.titleSynthesis, characterization and anticancer activity in vitro evaluation of novel dicyanoaurate (I)-based complexes
dc.typeArticle

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