Deniz et al: Neuroprotection by luteolin in diabetes Luteolin mitigates hippocampal damage in a rat model of streptozotocin-induced diabetes

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dc.contributor.authorDeniz, Omur Gulsum
dc.contributor.authorSoyturk, Hayriye
dc.contributor.authorIm, Aydin
dc.contributor.authorAgir, Dilek
dc.contributor.authorAnnac, Ebru
dc.date.accessioned2026-04-25T14:20:21Z
dc.date.available2026-04-25T14:20:21Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractDiabetes mellitus (DM) is a chronic metabolic disorder that poses a serious threat to human health by causing long-term damage to various vital organs. It leads to insulin resistance and disrupts carbohydrate, fat, and protein metabolism. This study aimed to investigate the protective effects of luteolin (Lut) against diabetes-induced damage in the hippocampus of rats, using immunohistochemical, histopathological, biochemical, and molecular approaches. Lut (20 mu g/kg, intraperitoneally (i.p.)) was administered to counteract hippocampal damage induced by diabetes, which was experimentally triggered using streptozotocin (STZ) at a dose of 50 mg/kg (i.p.). The experiment lasted 28 days and included 48 rats divided into six groups of eight: Control (Cont), DM, citrate buffer (CB, solvent), DM+Lut, Lut, and dimethyl sulfoxide (DMSO, solvent). In the DM group, there was a decrease in Bcl-2 gene expression and an increase in the expression levels of Bax, caspase-3, cytochrome c (Cyt c), ATF6, and IRE1, compared to the DM+Lut group. Histological analysis revealed greater neuronal degeneration, neuroinflammation, and apoptosis in the DM group than in the DM+Lut group. Biochemical analysis also supported these findings, as indicated by increased oxidative stress index (OSI) values. These results suggest that Lut mitigates the toxic effects of oxidative and endoplasmic reticulum stress, enhances antioxidant defenses, and supports hippocampal function. The findings demonstrate Lut's potential to prevent diabetes-induced hippocampal damage. Consequently, further research is strongly recommended to explore Lut as a therapeutic agent for diabetic neurodegeneration.
dc.description.sponsorshipBolu Abant Izzet Baysal University Scientific Research Projects (BAP) Coordination Unit [2022.08.03.1576]
dc.description.sponsorshipFunding: This study was supported by Bolu Abant Izzet Baysal University Scientific Research Projects (BAP) Coordination Unit (Project number: 2022.08.03.1576) .
dc.identifier.doi10.17305/bb.2025.12305
dc.identifier.endpage2383
dc.identifier.issn2831-0896
dc.identifier.issn2831-090X
dc.identifier.issue10
dc.identifier.orcid0000-0001-9254-175X
dc.identifier.orcid0000-0003-3279-1524
dc.identifier.pmid40332364
dc.identifier.scopus2-s2.0-105015641580
dc.identifier.scopusqualityQ1
dc.identifier.startpage2370
dc.identifier.urihttps://doi.org/10.17305/bb.2025.12305
dc.identifier.urihttps://hdl.handle.net/11486/8522
dc.identifier.volume25
dc.identifier.wosWOS:001483767500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo
dc.relation.ispartofBiomolecules and Biomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260420
dc.subjectDiabetes mellitus
dc.subjectluteolin
dc.subjecthippocampus
dc.subjectneurodegeneration
dc.subjectoxidative stress
dc.subjectendoplasmic reticulum stress
dc.titleDeniz et al: Neuroprotection by luteolin in diabetes Luteolin mitigates hippocampal damage in a rat model of streptozotocin-induced diabetes
dc.typeArticle

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