Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors

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dc.authoridGoren, Ahmet C/0000-0002-5470-130X
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridUSANMAZ, HANDE/0000-0003-3851-9601
dc.authoridAlmaz, Zuleyha/0000-0002-4532-4311
dc.authoridkoksal, zeynep/0000-0001-8203-4623
dc.contributor.authorKoksal, Zeynep
dc.contributor.authorKalin, Ramazan
dc.contributor.authorCamadan, Yasemin
dc.contributor.authorUsanmaz, Hande
dc.contributor.authorAlmaz, Zuleyha
dc.contributor.authorGulcin, Ilhami
dc.contributor.authorGokcen, Taner
dc.date.accessioned2025-03-23T19:26:19Z
dc.date.available2025-03-23T19:26:19Z
dc.date.issued2017
dc.departmentSinop Üniversitesi
dc.description.abstractSecondary sulfonamides (4a-8h) incorporating acetoxybenzamide, triacetoxybenzamide, hydroxybenzamide, and trihydroxybenzamide and possessing thiazole, pyrimidine, pyridine, isoxazole and thiadiazole groups were synthesized. Lactoperoxidase (LPO, E.C.1.11.1.7), as a natural antibacterial agent, is a peroxidase enzyme secreted from salivary, mammary, and other mucosal glands. In the present study, the in vitro inhibitory effects of some secondary sulfonamide derivatives (4a-8h) were examined against LPO. The obtained results reveal that secondary sulfonamide derivatives (4a-8h) are effective LPO inhibitors. The K-i values of secondary sulfonamide derivatives (4a-8h) were found in the range of 1.096 x 10(-3) to 1203.83 mu M against LPO. However, the most effective inhibition was found for N-(sulfathiazole)-3,4,5-triacetoxybenzamide (6a), with K-i values of 1.096 x 10(-3) +/- 0.471 x 10(-3) mu M as non-competitive inhibition.
dc.identifier.doi10.3390/molecules22060793
dc.identifier.issn1420-3049
dc.identifier.issue6
dc.identifier.pmid28538675
dc.identifier.scopus2-s2.0-85020688631
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/molecules22060793
dc.identifier.urihttps://hdl.handle.net/11486/4682
dc.identifier.volume22
dc.identifier.wosWOS:000404642100003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectlactoperoxidase
dc.subjectsecondary sulfonamide
dc.subjectenzyme purification
dc.subjectenzyme inhibition
dc.titleSecondary Sulfonamides as Effective Lactoperoxidase Inhibitors
dc.typeArticle

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