Microwave-assisted synthesis of primary aryl/heteroarylamines via one-pot reductive amination: A convenient and efficient synthetic route

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dc.contributor.authorSaral, Hasan
dc.contributor.authorOzdamar, Ozgur
dc.contributor.authorBekdemir, Yunus
dc.date.accessioned2025-03-23T19:41:11Z
dc.date.available2025-03-23T19:41:11Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractMicrowave-assisted copper-catalyzed amination process can be established for the conversion of aryl/heteroaryl bromides. The key features of this study include diverse aryl/heteroarylamine synthesis, the catalyst amount, shorter reaction time, high yields, a one-pot procedure, simple and commercially available starting materials, and moderate to good reaction yields. We have shown that using Cu(OAc)2 as a catalyst combined with ethylenediamine as an additive in the ethanol as solvent, greatly improved the reaction time and yield of this system compared to the previously reported conditions. The current catalytic system contributes a valuable route for preparing aminoquinoline and aminoisoquinoline as key precursors to obtain fine chemicals.
dc.identifier.doi10.1016/j.jics.2024.101539
dc.identifier.issn0019-4522
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85214290854
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.jics.2024.101539
dc.identifier.urihttps://hdl.handle.net/11486/6515
dc.identifier.volume102
dc.identifier.wosWOS:001414515900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of the Indian Chemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectPrimary arylamine
dc.subjectAryl bromide
dc.subjectMicrowave
dc.subjectAmination
dc.subjectSodium azide
dc.titleMicrowave-assisted synthesis of primary aryl/heteroarylamines via one-pot reductive amination: A convenient and efficient synthetic route
dc.typeArticle

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