Microwave-assisted synthesis of primary aryl/heteroarylamines via one-pot reductive amination: A convenient and efficient synthetic route
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Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Microwave-assisted copper-catalyzed amination process can be established for the conversion of aryl/heteroaryl bromides. The key features of this study include diverse aryl/heteroarylamine synthesis, the catalyst amount, shorter reaction time, high yields, a one-pot procedure, simple and commercially available starting materials, and moderate to good reaction yields. We have shown that using Cu(OAc)2 as a catalyst combined with ethylenediamine as an additive in the ethanol as solvent, greatly improved the reaction time and yield of this system compared to the previously reported conditions. The current catalytic system contributes a valuable route for preparing aminoquinoline and aminoisoquinoline as key precursors to obtain fine chemicals.
Açıklama
Anahtar Kelimeler
Primary arylamine, Aryl bromide, Microwave, Amination, Sodium azide
Kaynak
Journal of the Indian Chemical Society
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
102
Sayı
2
