Ameliorative effect of edible Halopteris scoparia against cadmium-induced reproductive toxicity in male mice: A biochemical and histopathologic study

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dc.authoridGUNER, ADEM/0000-0003-3295-3538
dc.authoridKavlak, Oya/0000-0003-3242-5313
dc.authoridKarabay Yavasoglu, N.Ulku/0000-0002-7483-0184
dc.authoridYavasoglu, Altug/0000-0003-4227-1637
dc.contributor.authorGuner, Ozlem
dc.contributor.authorGuner, Adem
dc.contributor.authorYavasoglu, Altug
dc.contributor.authorKarabay Yavasoglu, Nefise Ulku
dc.contributor.authorKavlak, Oya
dc.date.accessioned2025-03-23T19:32:04Z
dc.date.available2025-03-23T19:32:04Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractCadmium (Cd) is a toxic metal affecting the reproductive system. Halopteris scoparia (brown algae) is generally consumed as a salad in the Far East countries. This study was conducted to compare and determine the possible protective effects of H. scoparia and vitamin E and C combination (VEC) against cadmium chloride (CdCl2)-induced reproductive toxicity. A total of 36 male mice were equally divided into as control, CdCl2 (2 mg/kg), CdCl2 + H. scoparia (900 mg/kg), CdCl2 + VEC (200 mg/kg), H. scoparia alone and VEC alone groups. Blood and testis samples were taken for biochemical, histochemical and immunohistochemical analyses. H. scoparia was also examined for antioxidant activity (by DPPH assay) and mineral/trace element content (by ICP-MS method). CdCl2 exposure caused a significant deterioration in body weight, sperm parameters (count, motility, viability and morphology) (p < .001), histopathology, immunoreactivity and testosterone levels. However, H. scoparia improved CdCl2-induced deterioration effects more successfully than VEC-treated group. The present study suggests that edible H. scoparia can be used as a natural protective agent against Cd-induced testicular damage by possibly enhancing essential element levels or increasing antioxidant defence system.
dc.identifier.doi10.1111/and.13591
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue6
dc.identifier.pmid32320493
dc.identifier.scopus2-s2.0-85084053018
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/and.13591
dc.identifier.urihttps://hdl.handle.net/11486/5403
dc.identifier.volume52
dc.identifier.wosWOS:000527925600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectalgae
dc.subjectcadmium
dc.subjectoxidative stress
dc.subjectprotective effect
dc.subjecttestis
dc.titleAmeliorative effect of edible Halopteris scoparia against cadmium-induced reproductive toxicity in male mice: A biochemical and histopathologic study
dc.typeArticle

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