Comparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress

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dc.authoridBudak, Harun/0000-0002-7371-8959
dc.authoridDagdelen, Burak/0000-0002-4362-3852
dc.contributor.authorHukkamli, Berna
dc.contributor.authorDagdelen, Burak
dc.contributor.authorAydin, Feyza Sonmez
dc.contributor.authorBudak, Harun
dc.date.accessioned2025-03-23T19:42:36Z
dc.date.available2025-03-23T19:42:36Z
dc.date.issued2023
dc.departmentSinop Üniversitesi
dc.description.abstractThis study was conducted to compare the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress. Increased Il-1 and Il-6 expressions, markers of inflammation, were represented by inflammation models in mouse liver and kidney tissues injected intraperitoneally with LPS. After establishing the model, the GSH level and the GSH/GSSG ratio, which are oxidative stress markers, were investigated in both tissues treated with LPS and the control group. The expression of Trx1, TrxR, and Txnip genes increased in the liver tissues of LPS-treated mice. In the kidney tissue, while Trx1 expression decreased, no change was observed in TrxR1 expression, and Txnip expression increased. In the kidneys, TRXR1 and GR activities decreased, whereas GPx activity increased. In both tissues, the TRXR1 protein expression decreased significantly, while TXNIP expression increased. In conclusion, different behaviors of antioxidant system members were observed during acute inflammation in both tissues. Additionally, it can be said that the kidney tissue is more sensitive and takes earlier measures than the liver tissue against cellular damage caused by inflammation and inflammation-induced oxidative stress.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK) [114Z277]; Scientific Research Projects Coordination Commission of Atatuerk University [PRJ2016/151]; Council of Higher Education (CoHE) Scientific and Technological Research of Tuerkiye (TUEBITAK) [2211]
dc.description.sponsorshipThis work was financed by the Scientific and Technological Research Council of Turkiye (TUBITAK) (Project No.114Z277) and the Scientific Research Projects Coordination Commission of Atatuerk University (Project no. PRJ2016/151). Further-more, one author (Feyza Soenmez Aydin, Ph.D.) was supported by the Council of Higher Education (CoHE) Scientific and Technological Research of Tuerkiye (TUEBITAK) 2211- A Ph.D. ScholarshipProgram.
dc.identifier.doi10.1007/s12013-023-01126-3
dc.identifier.endpage311
dc.identifier.issn1085-9195
dc.identifier.issn1559-0283
dc.identifier.issue2
dc.identifier.pmid36773183
dc.identifier.scopus2-s2.0-85147751715
dc.identifier.scopusqualityQ2
dc.identifier.startpage299
dc.identifier.urihttps://doi.org/10.1007/s12013-023-01126-3
dc.identifier.urihttps://hdl.handle.net/11486/6807
dc.identifier.volume81
dc.identifier.wosWOS:000932723300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofCell Biochemistry and Biophysics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectInflammation
dc.subjectOxidative stress
dc.subjectThioredoxin system
dc.subjectGlutathione system
dc.subjectExpression and activity
dc.titleComparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress
dc.typeArticle

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