Coronary artery calcification progression and long-term cardiovascular outcomes in renal transplant recipients: an analysis by the joint model

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dc.authoridalagoz, selma/0000-0001-5416-2257
dc.authoridozcan, seyda gul/0000-0002-4341-5252
dc.authoridBakir Kayi, Alev/0000-0003-0664-5822
dc.contributor.authorSeyahi, Nurhan
dc.contributor.authorAlagoz, Selma
dc.contributor.authorAtli, Zeynep
dc.contributor.authorOzcan, Seyda Gul
dc.contributor.authorTripepi, Giovanni
dc.contributor.authorBakir, Alev
dc.contributor.authorTrabulus, Sinan
dc.date.accessioned2025-03-23T19:34:20Z
dc.date.available2025-03-23T19:34:20Z
dc.date.issued2022
dc.departmentSinop Üniversitesi
dc.description.abstractBackground. Compared with the general population, the risk of death is substantially higher in renal transplant recipients than in age- and sex-matched individuals in the general population. In the general population, coronary artery calcification (CAC) predicts all-cause and cardiovascular mortality. In this study we aimed to analyse these relationships in renal transplant recipients. Methods. We examined 178 renal transplant patients in this prospective observational cohort study. We measured CAC with multidetector spiral computed tomography using the Agatston score at multiple time points. Overall, 411 scans were performed in 178 patients over an average 12.8 years follow-up. The clinical endpoint was a composite including all-cause death and non-fatal cardiovascular events. Data analysis was performed by the joint model. Results. During a follow-up of 12.862.4 years, coronary calcification progressed over time (P < 0.001) and the clinical endpoint occurred in 54 patients. In the analysis by the joint model, both the baseline CAC score and the CAC score progression were strongly associated with the incidence rate of the composite event [hazard ratio 1.261 (95% confidence interval 1.119-1.420), P = 0.0001]. [GRAPHICS] Conclusions. CAC at baseline and coronary calcification progression robustly predict the risk of death and cardiovascular events in renal transplant recipients. These findings support the hypothesis that the link between the calcifying arteriopathy of renal transplant patients and clinical end points in these patients is causal in nature.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [BYP-1258]
dc.description.sponsorshipThe present work was funded by the Scientific Research Projects Coordination Unit of Istanbul University (Project BYP-1258).
dc.identifier.doi10.1093/ckj/sfab174
dc.identifier.endpage108
dc.identifier.issn2048-8505
dc.identifier.issn2048-8513
dc.identifier.issue1
dc.identifier.pmid35106150
dc.identifier.scopus2-s2.0-85124912345
dc.identifier.scopusqualityQ1
dc.identifier.startpage101
dc.identifier.urihttps://doi.org/10.1093/ckj/sfab174
dc.identifier.urihttps://hdl.handle.net/11486/5654
dc.identifier.volume15
dc.identifier.wosWOS:000743244500012
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofClinical Kidney Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectcardiovascular disease
dc.subjectcoronary artery calcification
dc.subjectjoint model
dc.subjectmortality
dc.subjectrenal transplantation
dc.titleCoronary artery calcification progression and long-term cardiovascular outcomes in renal transplant recipients: an analysis by the joint model
dc.typeArticle

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