Protective Effect of Boric Acid Against Ochratoxin A-Induced Toxic Effects in Human Embryonal Kidney Cells (HEK293): A Study on Cytotoxic, Genotoxic, Oxidative, and Apoptotic Effects

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dc.authoridAKKAN, TAMER/0000-0002-9866-4475
dc.authoridGUNER, ADEM/0000-0003-3295-3538
dc.authoridTekin, Askin/0000-0002-0362-9387
dc.contributor.authorTekin, Askin
dc.contributor.authorGuner, Adem
dc.contributor.authorAkkan, Tamer
dc.date.accessioned2025-03-23T19:42:36Z
dc.date.available2025-03-23T19:42:36Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractThe present study evaluates the protective properties of boric acid (BA) against the toxic effects induced by ochratoxin A (OTA) in human embryonic kidney cells (HEK293). The focus is on various parameters such as cytotoxicity, genotoxicity, oxidative stress, and apoptosis. OTA is a known mycotoxin that has harmful effects on the liver, kidneys, brain, and nervous system. BA, on the other hand, a boron-based compound, is known for its potential as a vital micronutrient with important cellular functions. The results show that BA administration not only increases cell viability but also mitigates the cytotoxic effects of OTA. This is evidenced by a reduction in the release of lactate dehydrogenase (LDH), indicating less damage to cell membranes. In addition, BA shows efficacy in reducing genotoxic effects, as the frequency of micronucleus (MN) and chromosomal aberrations (CA) decreases significantly, suggesting a protective role against DNA damage. In addition, the study shows that treatment with BA leads to a decrease in oxidative stress markers, highlighting its potential as a therapeutic intervention against the deleterious effects of OTA. These results emphasize the need for further research into the protective mechanisms of boron, particularly BA, in combating cell damage caused by OTA.
dc.description.sponsorshipGiresun University
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.1007/s12011-024-04194-5
dc.identifier.endpage821
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2
dc.identifier.pmid38713435
dc.identifier.scopus2-s2.0-85192228751
dc.identifier.scopusqualityQ1
dc.identifier.startpage810
dc.identifier.urihttps://doi.org/10.1007/s12011-024-04194-5
dc.identifier.urihttps://hdl.handle.net/11486/6809
dc.identifier.volume203
dc.identifier.wosWOS:001215577500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectOchratoxin A
dc.subjectBoric acid
dc.subjectProtective effect
dc.subjectGenotoxicity
dc.titleProtective Effect of Boric Acid Against Ochratoxin A-Induced Toxic Effects in Human Embryonal Kidney Cells (HEK293): A Study on Cytotoxic, Genotoxic, Oxidative, and Apoptotic Effects
dc.typeArticle

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