Synthesis and description of intermolecular interactions in new sulfonamide derivatives of tranexamic acid

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dc.authoridAsiri, Abdullah/0000-0001-7905-3209
dc.authoridButt, Rabia Ayub/0000-0002-4690-0552
dc.authoridAshfaq, Muhammad/0000-0002-6671-0908
dc.authoridDanish, Muhammad/0000-0001-6361-4016
dc.authoridSahin, Onur/0000-0003-3765-3235
dc.authoridZolotarev, Pavel/0000-0001-8512-5512
dc.contributor.authorAshfaq, Muhammad
dc.contributor.authorArshad, Muhammad Nadeem
dc.contributor.authorDanish, Muhammad
dc.contributor.authorAsiri, Abdullah M.
dc.contributor.authorKhatoon, Sadia
dc.contributor.authorMustafa, Ghulam
dc.contributor.authorZolotarev, Pavel N.
dc.date.accessioned2025-03-23T19:40:47Z
dc.date.available2025-03-23T19:40:47Z
dc.date.issued2016
dc.departmentSinop Üniversitesi
dc.description.abstractTranexamic acid (4-aminomethyl-cyclohexanecarboxylic acid) was reacted with sulfonyl chlorides to produce structurally related four sulfonamide derivatives using simple and environmental friendly method to check out their three-dimensional behavior and van der Walls interactions. The molecules were crystallized in different possibilities, as it is/after alkylation at its O and N atoms/along with a co-molecule. All molecules were crystallized in monoclinic crystal system with space group P2(1)/n, P2(1)/c and P2(1)/a. X-ray studies reveal that the molecules stabilized themselves by different kinds of hydrogen bonding interactions. The molecules are getting connected through O-H center dot center dot center dot O hydrogen bonds to form inversion dimers which are further connected through N-H center dot center dot center dot O interactions. The molecules in which N and 0 atoms were alkylated showed non-classical interaction and generated centro-symmetric R-2(2)(24) ring motif. The co-crystallized host and guest molecules are connected to each other via O-H center dot center dot center dot O interactions to generate different ring motifs. By means of the ToposPro software an analysis of the topologies of underlying nets that correspond to molecular packings and hydrogen-bonded networks in structures under consideration was carried out. (C) 2015 Elsevier B.V. All rights reserved.
dc.description.sponsorshipHEC Pakistan [2549]; Russian government [14.825.31.0005]; Russian Foundation for Basic Research [13-07-00001]; Deanship of Scientific Research (DSR), King Abdulaziz University [3-102/428]; KAU
dc.description.sponsorshipM.A and M.D. acknowledge to HEC Pakistan for providing grant under the project no. 2549. P.N.Z. thanks Russian government (grant No. 14.825.31.0005) and Russian Foundation for Basic Research (grant No. 13-07-00001) for support as well as Prof. Vladislav A. Blatov, Prof. Davide and M. Proserpio for fruitful discussion of the work. The authors acknowledge GC University, Lahore, Pakistan for data collection. This work was also funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, under Research Group Track of Grant No. (3-102/428). The authors, therefore, acknowledge technical and financial support of KAU.
dc.identifier.doi10.1016/j.molstruc.2015.09.022
dc.identifier.endpage280
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-84943551227
dc.identifier.scopusqualityQ1
dc.identifier.startpage271
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2015.09.022
dc.identifier.urihttps://hdl.handle.net/11486/6410
dc.identifier.volume1103
dc.identifier.wosWOS:000364726700031
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectTranexamic acid
dc.subjectSulfonamide
dc.subjectCrystallization
dc.subjectTopological aspects of structure
dc.titleSynthesis and description of intermolecular interactions in new sulfonamide derivatives of tranexamic acid
dc.typeArticle

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