Synthesis and description of intermolecular interactions in new sulfonamide derivatives of tranexamic acid
[ X ]
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Tranexamic acid (4-aminomethyl-cyclohexanecarboxylic acid) was reacted with sulfonyl chlorides to produce structurally related four sulfonamide derivatives using simple and environmental friendly method to check out their three-dimensional behavior and van der Walls interactions. The molecules were crystallized in different possibilities, as it is/after alkylation at its O and N atoms/along with a co-molecule. All molecules were crystallized in monoclinic crystal system with space group P2(1)/n, P2(1)/c and P2(1)/a. X-ray studies reveal that the molecules stabilized themselves by different kinds of hydrogen bonding interactions. The molecules are getting connected through O-H center dot center dot center dot O hydrogen bonds to form inversion dimers which are further connected through N-H center dot center dot center dot O interactions. The molecules in which N and 0 atoms were alkylated showed non-classical interaction and generated centro-symmetric R-2(2)(24) ring motif. The co-crystallized host and guest molecules are connected to each other via O-H center dot center dot center dot O interactions to generate different ring motifs. By means of the ToposPro software an analysis of the topologies of underlying nets that correspond to molecular packings and hydrogen-bonded networks in structures under consideration was carried out. (C) 2015 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Tranexamic acid, Sulfonamide, Crystallization, Topological aspects of structure
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
1103
