Protective effects of curcumin and Ganoderma lucidum on hippocampal damage caused by the organophosphate insecticide chlorpyrifos in the developing rat brain: Stereological, histopathological and immunohistochemical study

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dc.authoridsagir, dilek/0000-0002-6862-988X
dc.contributor.authorEronat, Kubra
dc.contributor.authorSagir, Dilek
dc.date.accessioned2025-03-23T19:42:10Z
dc.date.available2025-03-23T19:42:10Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractThe aim of this study is to draw attention to the possible effects of chlorpyrifos exposure on the developing rat hippocampus in the prenatal period and to determine whether these effects can be reduced with various antioxidant substances. Pregnant rats were divided into 7 groups.; Chlorpyrifos (CPF), Curcumin (CUR), Ganoderma lucidum (GNL), Chlorpyrifos + Curcumin (CPF + CUR), Chlorpyrifos + Ganoderma lucidum, (CPF + GNU SHAM and Control (C). After the experiments, brain tissues were evaluated by stereological and immunohistochemical methods. As a result of the stereological analyzes, it was determined that the number of pyramidal neurons in the hippocampus of the CPF group decreased significantly from all other groups. In contrast, the number of neurons in the CPF + CUR and CPF + GNL groups was significantly higher than the CPF group. In addition, immunohistochemical analyzes showed that the density of cells stained with glial fibrillar acidic protein (GFAP) positive in all areas in the hippocampus of the rats in the CPF group was significantly higher compared to the control group, whereas in the CPF + CUR and CPF + GNL groups were less than the CPF group. As a result, the exposure of CPF in the prenatal period caused neurotoxicity in the brain hippocampus, whereas CUR and GNL reduced this toxicity caused by CPF.
dc.description.sponsorshipSinop University [SYO-1901-16-36]
dc.description.sponsorshipIt was supported by SYO-1901-16-36 project of Sinop University Scientific Research Projects Coordinator.
dc.identifier.doi10.1016/j.acthis.2020.151621
dc.identifier.issn0065-1281
dc.identifier.issn1618-0372
dc.identifier.issue7
dc.identifier.pmid33066842
dc.identifier.scopus2-s2.0-85090415943
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2020.151621
dc.identifier.urihttps://hdl.handle.net/11486/6721
dc.identifier.volume122
dc.identifier.wosWOS:000581062600015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofActa Histochemica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectChlorpyrifos
dc.subjectCurcumin
dc.subjectGanoderma lucidum
dc.subjectHippocampus
dc.subjectNeurotoxicity
dc.subjectGlial fibrillar acidic protein (GFAP)
dc.titleProtective effects of curcumin and Ganoderma lucidum on hippocampal damage caused by the organophosphate insecticide chlorpyrifos in the developing rat brain: Stereological, histopathological and immunohistochemical study
dc.typeArticle

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