Investigation of CCL1 rs159294 T/A gene polymorphism in pulmonary and extrapulmonary tuberculosis patients

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dc.authoridSen, Deniz/0000-0003-1554-3297
dc.contributor.authorOzdemir, Fethi Ahmet
dc.contributor.authorErol, Deniz
dc.contributor.authorYuce, Hueyin
dc.contributor.authorKonar, Vahit
dc.contributor.authorSenli, Ebru Kara
dc.contributor.authorBulut, Funda
dc.contributor.authorDeveci, Figen
dc.date.accessioned2025-03-23T19:25:34Z
dc.date.available2025-03-23T19:25:34Z
dc.date.issued2013
dc.departmentSinop Üniversitesi
dc.description.abstractIntroduction: The purpose of this study is to reveal whether CCL1 rs159294 T/A polymorphism in pulmonary and extrapulmonary tuberculosis patients pose a risk to catch tuberculosis or not. Materials and Methods: In the study, peripheral blood samples from the control group, which includes 160 patients, who consulted to Firat University Faculty of Medicine, Pulmonology Policlinic in Elazig province and who were diagnosed with tuberculosis; and 160 healthy individuals, were taken and put into tubes containing EDTA. Each tube contained 2 cc blood samples. DNA isolation was made from these blood samples and CCL1 rs159294 T/A polymorphism was defined with PCR-RFLP analysis. Results: For CCL1 rs159294 T/A polymorphism, TT genotype was found in 98 (61.3%) patients, TA genotype was found in 58 (36.3%) patients, AA genotype was found in 4 (2.5%) patients among 160 patients with tuberculosis; and TT genotype was found in 50 (70.4%) patients, TA genotype in 20 (28.2%) patients, AA genotype was found in 1 (1.4%) patient among 71 patients with pulmonary tuberculosis; TT genotype was found in 48 (53.9%) patients TA genotype was found in 38 (42.7%) patients and AA genotype was found in 3 (3.4%) patients among 89 extrapulmonary tuberculosis patients. And in control group, among 160 healthy individuals, TT genotype was found in 100 (62.5%) individuals, TA genotype was found in 58 (36.3%) individuals, AA genotype was found in 2 (1.3%) individuals and no statistically significant difference was found. Conclusion: CCL1 rs159294 T/A polymorphism do not form an inclination to tuberculosis in our population.
dc.identifier.doi10.5578/tt.5481
dc.identifier.endpage208
dc.identifier.issn0494-1373
dc.identifier.issue3
dc.identifier.pmid24298961
dc.identifier.scopus2-s2.0-84888774242
dc.identifier.scopusqualityQ3
dc.identifier.startpage200
dc.identifier.urihttps://doi.org/10.5578/tt.5481
dc.identifier.urihttps://hdl.handle.net/11486/4504
dc.identifier.volume61
dc.identifier.wosWOS:000421333900004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isotr
dc.publisherTurkish Assoc Tuberculosis & Thorax
dc.relation.ispartofTuberkuloz Ve Torak-Tuberculosis and Thorax
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectPulmonary tuberculosis
dc.subjectextrapulmonary tuberculosis
dc.subjectCCL1
dc.subjectpolymorphism
dc.titleInvestigation of CCL1 rs159294 T/A gene polymorphism in pulmonary and extrapulmonary tuberculosis patients
dc.typeArticle

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