A polymeric copper complex based on a pyrazole derivative: Synthesis, spectroscopic, X-ray, and biological activity studies

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dc.authoridMeseha, Mina/0000-0002-8805-8009
dc.authoridSahin, Onur/0000-0003-3765-3235
dc.authoridDiker, Halide/0000-0002-1410-6055
dc.contributor.authorAmin, Mina A.
dc.contributor.authorDiker, Halide
dc.contributor.authorSahin, Onur
dc.contributor.authorVarlikli, Canan
dc.contributor.authorSoliman, Ahmed A.
dc.date.accessioned2025-03-23T19:47:16Z
dc.date.available2025-03-23T19:47:16Z
dc.date.issued2024
dc.departmentSinop Üniversitesi
dc.description.abstractA novel 1D coordination polymeric copper complex based on 4-(4 '-nitrophenylhydrazono)-5-trifluoromethyl-2,4-dihydropyrazol-3-one was prepared and characterized spectroscopically and thermally and via X-ray crystallographic investigation. The prepared copper-based structure was proved to have a 1D coordination polymer. X-ray studies showed that the polymeric copper complex was of octahedral geometry, the ligand acted as a bidentate ligand, and the nitro group attached to the ligand acted as a bridging group. The cytotoxic activities of the copper polymer were evaluated including against MCF-7 cells (breast cancer cell line), HepG-2 cells (hepatocellular carcinoma), and HCT-116 cells (colon cancer cell line). The morphological alterations of the complex treated cells were investigated using an inverted microscope. The cell cycle and apoptosis were evaluated and reported. The copper polymer exhibited the best antitumor activity against HepG-2 cells (35.22 +/- 4.80 mu M) while also causing a decline in the G2/M phase and a remarkable enhancement in the early apoptosis. A novel polymeric Cu (II) complex based on 4-(4 '-nitrophenylhydrazono)-5-trifluoromethyl-2,4-dihydropyrazol-3-one was prepared and characterized by spectroscopic, thermal, and X-ray crystallographic analysis techniques. The structure of the prepared complex was proved to have a polymeric nature with a copper center of octahedral geometry. The cytotoxic activities of the polymeric Cu (II) complex were evaluated including against mammalian cell lines: MCF-7 cells (human breast cancer cell line), HepG-2 cells (human hepatocellular carcinoma), and HCT-116 cells (human colon cancer cell line). image
dc.identifier.doi10.1002/aoc.7592
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue8
dc.identifier.scopus2-s2.0-85195664672
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/aoc.7592
dc.identifier.urihttps://hdl.handle.net/11486/7324
dc.identifier.volume38
dc.identifier.wosWOS:001244545500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofApplied Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectbiological activity
dc.subjectcopper polymer
dc.subjectligand
dc.titleA polymeric copper complex based on a pyrazole derivative: Synthesis, spectroscopic, X-ray, and biological activity studies
dc.typeArticle

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