A polymeric copper complex based on a pyrazole derivative: Synthesis, spectroscopic, X-ray, and biological activity studies
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Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A novel 1D coordination polymeric copper complex based on 4-(4 '-nitrophenylhydrazono)-5-trifluoromethyl-2,4-dihydropyrazol-3-one was prepared and characterized spectroscopically and thermally and via X-ray crystallographic investigation. The prepared copper-based structure was proved to have a 1D coordination polymer. X-ray studies showed that the polymeric copper complex was of octahedral geometry, the ligand acted as a bidentate ligand, and the nitro group attached to the ligand acted as a bridging group. The cytotoxic activities of the copper polymer were evaluated including against MCF-7 cells (breast cancer cell line), HepG-2 cells (hepatocellular carcinoma), and HCT-116 cells (colon cancer cell line). The morphological alterations of the complex treated cells were investigated using an inverted microscope. The cell cycle and apoptosis were evaluated and reported. The copper polymer exhibited the best antitumor activity against HepG-2 cells (35.22 +/- 4.80 mu M) while also causing a decline in the G2/M phase and a remarkable enhancement in the early apoptosis. A novel polymeric Cu (II) complex based on 4-(4 '-nitrophenylhydrazono)-5-trifluoromethyl-2,4-dihydropyrazol-3-one was prepared and characterized by spectroscopic, thermal, and X-ray crystallographic analysis techniques. The structure of the prepared complex was proved to have a polymeric nature with a copper center of octahedral geometry. The cytotoxic activities of the polymeric Cu (II) complex were evaluated including against mammalian cell lines: MCF-7 cells (human breast cancer cell line), HepG-2 cells (human hepatocellular carcinoma), and HCT-116 cells (human colon cancer cell line). image
Açıklama
Anahtar Kelimeler
biological activity, copper polymer, ligand
Kaynak
Applied Organometallic Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
38
Sayı
8
