Plantago major Protective Effects on Antioxidant Status after Administration of 7,12-Dimethylbenz(a)anthracene in Rats

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dc.authoridyasar, semih/0000-0003-2754-6030
dc.authoridYasar, Semih/0000-0002-2149-405X
dc.authoridLevent, Abdulkadir/0000-0001-5792-419X
dc.authoridEkin, Suat/0000-0002-6502-5028
dc.authoridOzdemir, Hulya/0000-0002-6045-8342
dc.contributor.authorOto, Gokhan
dc.contributor.authorEkin, Suat
dc.contributor.authorOzdemir, Hulya
dc.contributor.authorDemir, Halit
dc.contributor.authorYasar, Semih
dc.contributor.authorLevent, Abdulkadir
dc.contributor.authorBerber, Ismet
dc.date.accessioned2025-03-23T19:48:49Z
dc.date.available2025-03-23T19:48:49Z
dc.date.issued2011
dc.departmentSinop Üniversitesi
dc.description.abstractAim: The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA). Methods: Rats were divided into three equal groups of 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and group 3 receiving the DMBA and the aqueous extract at 100 mg/kg/d for 60 days. Results: Significant decrease in catalase (P<0.05), carbonic anhydrase (p <= 0.01), reduced glutathione (GSH) (P<0.01) and total protein (P<0.01) values was observed in the DMBA group compared with the healthy controls and DMBA + Plantago major groups. Conclusion: The results suggest preventive effects of Plantago major on DMBA induced oxidative damage in Wistar albino rats that might be due to decreased free radical generation.
dc.description.sponsorshipPresidency of Yuzuncu Yil University [2008-FED-B083]
dc.description.sponsorshipThis study was supported by a grant from the Scientific Research Projects Presidency of Yuzuncu Yil University (2008-FED-B083).
dc.identifier.endpage535
dc.identifier.issn1513-7368
dc.identifier.issue2
dc.identifier.pmid21545225
dc.identifier.scopus2-s2.0-79958782513
dc.identifier.scopusqualityQ3
dc.identifier.startpage531
dc.identifier.urihttps://hdl.handle.net/11486/7665
dc.identifier.volume12
dc.identifier.wosWOS:000293172800035
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAsian Pacific Organization Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectAntioxidant
dc.subjectDMBA
dc.subjectlipid peroxidation
dc.subjectplantago major
dc.subjectrat
dc.titlePlantago major Protective Effects on Antioxidant Status after Administration of 7,12-Dimethylbenz(a)anthracene in Rats
dc.typeArticle

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