Molecularly imprinted electrochemical biosensor based on Fe@Au nanoparticles involved in 2-aminoethanethiol functionalized multi-walled carbon nanotubes for sensitive determination of cefexime in human plasma

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dc.authoridAtar, Necip/0000-0001-8779-1412
dc.contributor.authorYola, Mehmet Lutfi
dc.contributor.authorEren, Tanju
dc.contributor.authorAtar, Necip
dc.date.accessioned2025-03-23T19:41:56Z
dc.date.available2025-03-23T19:41:56Z
dc.date.issued2014
dc.departmentSinop Üniversitesi
dc.description.abstractThe molecular imprinting technique depends on the molecular recognition. It is a polymerization method around the target molecule. Hence, this technique creates specific cavities in the cross-linked polymeric matrices. In present study, a sensitive imprinted electrochemical biosensor based on Fe@Au nanoparticles (Fe@AuNPs) involved in 2-aminoethanethiol (2-AET) functionalized multi-walled carbon nanotubes (f-MWCNs) modified glassy carbon (GC) electrode was developed for determination of cefexime (CEF). The results of X-ray photoelectron spectroscopy (XPS) and reflection-absorption infrared spectroscopy (RAIRS) confirmed the formation of the developed surfaces. CEF imprinted film was constructed by cyclic voltammetry (CV) for 9 cycles in the presence of 80 mM pyrrole in phosphate buffer solution (pH 6.0) containing 20 mM CEF. The developed electrochemical biosensor was validated according to the International Conference on Harmonisation (ICH) guideline and found to be linear, sensitive, selective, precise and accurate. The linearity range and the detection limit were obtained as 1.0 x 10(-10)-1.0 x 10(-8) M and 2.2 x 10(-11) M, respectively. The developed CEF imprinted sensor was successfully applied to real samples such as human plasma. In addition, the stability and reproducibility of the prepared molecular imprinted electrode were investigated. The excellent long-term stability and reproducibility of the prepared CEF imprinted electrodes make them attractive in electrochemical sensors. (C) 2014 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.bios.2014.04.045
dc.identifier.endpage285
dc.identifier.issn0956-5663
dc.identifier.issn1873-4235
dc.identifier.pmid24832202
dc.identifier.scopus2-s2.0-84900001619
dc.identifier.scopusqualityQ1
dc.identifier.startpage277
dc.identifier.urihttps://doi.org/10.1016/j.bios.2014.04.045
dc.identifier.urihttps://hdl.handle.net/11486/6686
dc.identifier.volume60
dc.identifier.wosWOS:000337863900040
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Advanced Technology
dc.relation.ispartofBiosensors & Bioelectronics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectMolecularly imprinting
dc.subjectCefexime
dc.subjectFe@Au nanoparticles
dc.subjectMulti-walled carbon nanotubes
dc.subjectValidation
dc.subjectHuman plasma
dc.titleMolecularly imprinted electrochemical biosensor based on Fe@Au nanoparticles involved in 2-aminoethanethiol functionalized multi-walled carbon nanotubes for sensitive determination of cefexime in human plasma
dc.typeArticle

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