Synthesis and characterization of stimuli-responsive hydrogels: evaluation of external stimuli influence on L929 fibroblast viability

Basit Öğe Kaydı
dc.authoridUzun, Lokman/0000-0002-3971-7725
dc.authoridCorman, Mehmet Emin/0000-0001-9062-4201
dc.authoridOzturk-Oncel, M.Ozgen/0000-0001-8576-2845
dc.contributor.authorKarasu, Tunca
dc.contributor.authorErkoc-Biradli, Fatma Zehra
dc.contributor.authorOzturk-Oncel, M. Ozgen
dc.contributor.authorArmutcu, Canan
dc.contributor.authorUzun, Lokman
dc.contributor.authorGaripcan, Bora
dc.contributor.authorCorman, Mehmet Emin
dc.date.accessioned2025-03-23T19:34:20Z
dc.date.available2025-03-23T19:34:20Z
dc.date.issued2022
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, poly(2-hydroxyethylmethacrylate) [p(HEMA)] based hydrogels responsive to the pH, temperature and magnetic field were synthesized. The surface properties of p(HEMA) were improved by designing the stimuli-responsive hydrogels made of MAGA, NIPAAm and methacrylate-decorated magnetite nanoparticles as a function of pH-, thermo- and magnetic responsive cell culture surfaces. These materials were then modified an abundant extracellular matrix component, type I collagen, which has been considered as a biorecognition element to increase the applicability of hydrogels to cell viability. Based on results from scanning electronmicroscopy (SEM) and thermal gravimetric analysis (TGA), stimuli-responsive hydrogel demonstrated improved non-porous structures and thermal stability with a high degree of cross-linking. Mechanical analyses of the hydrogels also showed that stimuli-responsive hydrogels are more elastomeric due to the polymeric chains and heterogeneous amorphous segments compared to plain hydrogels. Furthermore, surface modification of hydrogels with collagen provided better biocompatibility, which was confirmed with L929 fibroblast cell adhesion. Produced stimuli-responsive hydrogels modulated cellular viability by changing pH and magnetic field.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-KBAG-117Z166]
dc.description.sponsorshipThis study was supported by The Scientific and Technological Research Council of Turkey with a grant number of TUBITAK-KBAG-117Z166.
dc.identifier.doi10.1088/2057-1976/ac7baa
dc.identifier.issn2057-1976
dc.identifier.issue5
dc.identifier.pmid35738237
dc.identifier.scopus2-s2.0-85134083652
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1088/2057-1976/ac7baa
dc.identifier.urihttps://hdl.handle.net/11486/5657
dc.identifier.volume8
dc.identifier.wosWOS:000820850000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIop Publishing Ltd
dc.relation.ispartofBiomedical Physics & Engineering Express
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectamino acid decoration
dc.subjectcollagen
dc.subjectstimuli-responsive polymers
dc.subjectamino acid decoration
dc.subjectcollagen
dc.subjectstimuli-responsive polymers
dc.titleSynthesis and characterization of stimuli-responsive hydrogels: evaluation of external stimuli influence on L929 fibroblast viability
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu