Association of Human Endogenous Retrovirus HERV-K18 Variant with Bipolar Disorder Type I

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dc.contributor.authorYegin, Zeynep
dc.contributor.authorSarisoy, Gokhan
dc.contributor.authorAvsar, Cumhur
dc.contributor.authorAral, Ayse Erguner
dc.contributor.authorKoc, Haydar
dc.date.accessioned2026-04-25T14:20:35Z
dc.date.available2026-04-25T14:20:35Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractObjective: Human endogenous retroviruses (HERVs) and associated sequences occupy similar to 8% of the human genome and dysregulation of HERV transcripts may have significant impacts on human health including psychiatric disorders. HERV-K18 is still active in the human genome and its envelope gene encodes a superantigen (SAg) which may result in deregulation of the immune system. In the study, the possible associations of the two variants localized in the SAg-coding region of HERV-K18 with bipolar disorder type I (BD-I) were evaluated. Methods: The subjects included 100 patients with BD-I and 100 age- and sex-matched healthy controls. The effects of the two HERV-K18 variants (HERV-8594 and HERV-8914) were analyzed with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The possible associations of the genotypes/alleles in BD-I patients with several clinical and demographic data were also evaluated. Results: HERV-8914 TT genotype had approximately 5.36 times higher risk of BD-I than those with the CC genotype (odds ratio, 5.386; 95% confidence interval, 1.602-18.110). Moreover, the prevalence of the CC genotype in patients with hypomania (31.25%) was found to be higher than that observed in patients without hypomania (10.71%) (Fisher's Conclusion: This is the first study implying that HERV-K18 variations may be associated with the pathogenesis of BD-I.
dc.identifier.doi10.9758/cpn.24.1242
dc.identifier.endpage285
dc.identifier.issn1738-1088
dc.identifier.issn2093-4327
dc.identifier.issue2
dc.identifier.orcid0000-0001-6085-3724
dc.identifier.orcid0000-0002-4095-0022
dc.identifier.pmid40223262
dc.identifier.scopus2-s2.0-105003456161
dc.identifier.scopusqualityQ2
dc.identifier.startpage278
dc.identifier.urihttps://doi.org/10.9758/cpn.24.1242
dc.identifier.urihttps://hdl.handle.net/11486/8643
dc.identifier.volume23
dc.identifier.wosWOS:001530416100008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Coll Neuropsychopharmacology
dc.relation.ispartofClinical Psychopharmacology and Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260420
dc.subjectBipolar disorder
dc.subjectEndogenous retroviruses
dc.subjectHERV-K18
dc.subjectGenetic variation
dc.titleAssociation of Human Endogenous Retrovirus HERV-K18 Variant with Bipolar Disorder Type I
dc.typeArticle

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