Synthesis, crystal structure and biological evaluation of spectroscopic characterization of Ni(II) and Co(II) complexes with N-salicyloil-N-maleoil-hydrazine as anticholinergic and antidiabetic agents

Basit Öğe Kaydı
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridSucayev, Afsun/0000-0002-4135-9568
dc.authoridHuseynova, Mansura/0000-0002-1534-6819
dc.authoridFarzaliyev, Vagif/0009-0004-4301-475X
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authoridGondolova, Gulnar/0000-0002-5441-7704
dc.contributor.authorGondolova, Gulnar
dc.contributor.authorTaslimi, Parham
dc.contributor.authorMedjidov, Ajdar
dc.contributor.authorFarzaliyev, Vagif
dc.contributor.authorSujayev, Afsun
dc.contributor.authorHuseynova, Mansura
dc.contributor.authorSahin, Onur
dc.date.accessioned2025-03-23T19:47:10Z
dc.date.available2025-03-23T19:47:10Z
dc.date.issued2018
dc.departmentSinop Üniversitesi
dc.description.abstract[Ni(C11H9N2O5)(2)(H2O)(2)]center dot 3(C3H7NO) (1) and [Co(C11H9N2O5)(2)(H2O)(2)]center dot 3(C3H7NO) (2) are synthesized and characterized by elemental analysis, FT-IR spectra, magnetic susceptibility, and thermal analysis. In addition, the crystal structure of Ni(II) complex is presented. Both complexes show distorted octahedral geometry. In 1 and 2, metal ions are coordinated by two oxygen atoms of salicylic residue and two nitrogen atoms of maleic amide residue from two ligands, and two oxygen atoms from two water molecules. In this paper, both compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I, and II, -glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Compounds 1 and 2 had Ki values of 18.36 +/- 4.38 and 26.61 +/- 7.54 nM against hCA I and 13.81 +/- 3.02 and 29.56 +/- 6.52 nM against hCA II, respectively. On the other hand, their Ki values were found to be 487.45 +/- 54.18 and 453.81 +/- 118.61 nM against AChE and 199.21 +/- 50.35 and 409.41 +/- 6.86 nM against BChE, respectively.
dc.identifier.doi10.1002/jbt.22197
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue9
dc.identifier.pmid30044035
dc.identifier.scopus2-s2.0-85053627984
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.22197
dc.identifier.urihttps://hdl.handle.net/11486/7298
dc.identifier.volume32
dc.identifier.wosWOS:000445187100010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectcrystal structure
dc.subjectenzyme inhibition
dc.subjectmagnetic properties
dc.subjectN-salicyloil-N'-maleoil-hydrazine
dc.subjectsynthesis
dc.titleSynthesis, crystal structure and biological evaluation of spectroscopic characterization of Ni(II) and Co(II) complexes with N-salicyloil-N-maleoil-hydrazine as anticholinergic and antidiabetic agents
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu