Heterocyclic amides derived from 2-thiopheneacetic acid: Synthesis, characterization and antimicrobial activity evaluation

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dc.contributor.authorCakmak, Sukriye
dc.contributor.authorVeyisoglu, Aysel
dc.date.accessioned2025-03-23T19:17:08Z
dc.date.available2025-03-23T19:17:08Z
dc.date.issued2021
dc.departmentSinop Üniversitesi
dc.description.abstractSynthesized the heterocyclic amide derivatives (I-IV) were from 2-thiophene acetic acid in two steps. In the first step, the intermediate acylation agent formed and isolated, then subjected to aminolysis and obtained the corresponding amide derivatives. The structures of compounds obtained were characterized by FT-IR,13C NMR,1H NMR, spectroscopies and elemental analysis techniques. The antimicrobial activities of these four compounds against Gram-negative bacteria, Gram-positive bacteria and fungi were investigated using the minimum inhibition concentration method. As a result, compounds (I and III) exhibited better good antibacterial activities against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa compared to the commercially standard antibacterial agent of amoxicillin. © 2021, TUBITAK. All rights reserved.
dc.identifier.doi10.31202/ecjse.824619
dc.identifier.endpage396
dc.identifier.issn2148-3736
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85105077660
dc.identifier.scopusqualityQ4
dc.identifier.startpage389
dc.identifier.trdizinid1128574
dc.identifier.urihttps://doi.org/10.31202/ecjse.824619
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1128574
dc.identifier.urihttps://hdl.handle.net/11486/4280
dc.identifier.volume8
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTUBITAK
dc.relation.ispartofEl-Cezeri Journal of Science and Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250323
dc.subjectAcyl chloride
dc.subjectAminolysis
dc.subjectAntimicrobial activity
dc.subjectHeterocyclic amides
dc.subjectSpectroscopic evaluation
dc.titleHeterocyclic amides derived from 2-thiopheneacetic acid: Synthesis, characterization and antimicrobial activity evaluation
dc.title.alternative2-tiyofenasetik asitten türetilen heterosiklik amitler: Sentez, karakterizasyon ve antimikrobiyal aktivitesinin değerlendirilmesi
dc.typeArticle

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