Heterocyclic amides derived from 2-thiopheneacetic acid: Synthesis, characterization and antimicrobial activity evaluation
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Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TUBITAK
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Synthesized the heterocyclic amide derivatives (I-IV) were from 2-thiophene acetic acid in two steps. In the first step, the intermediate acylation agent formed and isolated, then subjected to aminolysis and obtained the corresponding amide derivatives. The structures of compounds obtained were characterized by FT-IR,13C NMR,1H NMR, spectroscopies and elemental analysis techniques. The antimicrobial activities of these four compounds against Gram-negative bacteria, Gram-positive bacteria and fungi were investigated using the minimum inhibition concentration method. As a result, compounds (I and III) exhibited better good antibacterial activities against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa compared to the commercially standard antibacterial agent of amoxicillin. © 2021, TUBITAK. All rights reserved.
Açıklama
Anahtar Kelimeler
Acyl chloride, Aminolysis, Antimicrobial activity, Heterocyclic amides, Spectroscopic evaluation
Kaynak
El-Cezeri Journal of Science and Engineering
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
8
Sayı
1
