SPECTRAL CHARACTERIZATION AND ANTIBACTERIAL, ANTIFUNGAL, ANTIVIRAL ACTIVITY OF SALICYL BASED NEW SCHIFF BASES AND THEIR Co(II), Ni(II), Cu(II), Zn(II), AND Pd(II) COMPLEXES **
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Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Editura Acad Romane
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Two new salicyl based Schiff bases derived from 3,5-dichlorosalicylaldehyde and 4-(chloro/ tert - butyl)-2-aminophenols ( H 2 L 1 and H 2 L 2 ) and their complexes with cobalt(II), nickel(II), copper(II), zinc(II), and palladium(II), {[M( L n )(H 2 O)]center dot x H 2 O, M(II) = Co(II) ( n = 1, 2; x = 1), Ni(II) ( n = 1, x = 2; n = 2, x = 0), Cu(II) ( n = 1, 2; x = 0), Zn(II) ( n = 1, 2; x = 0); K[Pd( L n )Cl]; n = 1, 2}, were synthesized and characterized. The structural characteristics of the complexes were examined by means of elemental analysis, molar conductivity, magnetic moment, thermogravimetric analysis (TGA), UVvisible, FT -IR, and NMR spectroscopy. In addition, the crystal structures of H 2 L 1 and H 2 L 2 were determined by X-ray single diffraction measurements. All the complexes are non -electrolyte with 1:1 M:L ratio. Antibacterial and antifungal activity of the compounds was evaluated against six bacteria and three fungi. In general, all the compounds showed moderate antimicrobial activity. Some of the complexes exhibited higher activity towards some microorganisms than the ligands. Antiviral activity of the compounds was tested against Parainfluenza Type -2 virus. The fact that H 2 L 2 has a higher antiviral effect than H 2 L 1 can be evaluated as that the tert -butyl group promotes the antiviral effect.
Açıklama
Anahtar Kelimeler
Transfer Radical Polymerization, Antimicrobial Activity, Metal-Complexes, Square-Planar, Biological-Activity, Crystal-Structure, Water Clusters, Mannich-Bases, Ruthenium, Nickel(Ii)
Kaynak
Revue Roumaine De Chimie
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
69
Sayı
1-2
