Lack of Association of 1513 A/C Polymorphism in P2X7 Gene with Susceptibility to 7 Pulmonary and Extrapulmonary Tuberculosis

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dc.authoridSen, Deniz/0000-0003-1554-3297
dc.authoridozdemir, Fethi Ahmet/0000-0001-7215-9692
dc.contributor.authorOzdemir, Fethi Ahmet
dc.contributor.authorErol, Deniz
dc.contributor.authorKonar, Vahit
dc.contributor.authorYuce, Hueyin
dc.contributor.authorSenli, Ebru Kara
dc.contributor.authorBulut, Funda
dc.contributor.authorDeveci, Figen
dc.date.accessioned2025-03-23T19:25:34Z
dc.date.available2025-03-23T19:25:34Z
dc.date.issued2014
dc.departmentSinop Üniversitesi
dc.description.abstractIntroduction: Tuberculosis, is one of the a leading causes of death worldwide, is characterized by different clinical forms including: latent, localized pulmonary infection and extrapulmonary tuberculosis. Candidate gene association studies have implicated common polymophisms in genes that may influence the development of tuberculosis. This study, aimed to elucidate the role of P2X(7) gene in 1513A/C polymorphism the etiopathogenesis of tuberculosis. Materials and Methods: The study included 160 patients with tuberculosis (71 pulmonary and 89 extrapulmonary tuberculosis) and 160 healthy controls. Genomic DNA was isolated and 1513A/C polymorphism in P2X(7) gene was genotyped by PCR-RFLP method. Results: Frequency of P2X(7) AA genotype was 47.5% in controls and 56.87% in patients, AC frequency was 39.37% controls and 32.5% in patients, CC genotype was 13.12% in controls and 10.62% in patients. No significant difference in allele and genotype frequencies (1513A/C polymorphism) between tuberculosis patients and controls was found. Conclusion: The results suggest that 1513A/C polymorphism of P2X(7) gene is not associated with pulmonary and extrapulmonary tuberculosis in the Eastern Turkey.
dc.description.sponsorshipScientific Research Projects Unit (FUBAP) of the Firat University [FF.10.01]
dc.description.sponsorshipThis study was sponsored by Scientific Research Projects Unit (FUBAP) of the Firat University (Project no: FF.10.01).
dc.identifier.doi10.5578/tt.4740
dc.identifier.endpage11
dc.identifier.issn0494-1373
dc.identifier.issue1
dc.identifier.pmid24814072
dc.identifier.scopus2-s2.0-84899764831
dc.identifier.scopusqualityQ3
dc.identifier.startpage7
dc.identifier.urihttps://doi.org/10.5578/tt.4740
dc.identifier.urihttps://hdl.handle.net/11486/4505
dc.identifier.volume62
dc.identifier.wosWOS:000421337600002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Assoc Tuberculosis & Thorax
dc.relation.ispartofTuberkuloz Ve Torak-Tuberculosis and Thorax
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectTuberculosis
dc.subjectP2X(7)
dc.subjectpolymorphism
dc.titleLack of Association of 1513 A/C Polymorphism in P2X7 Gene with Susceptibility to 7 Pulmonary and Extrapulmonary Tuberculosis
dc.typeArticle

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