Determination of antimicrobial and antimutagenic properties of some Schiff bases

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dc.authoridOGUTCU, HATICE/0000-0001-7100-9318
dc.authoridMeral, Seher/0000-0002-6309-8936
dc.authoridAgar, Guleray/0000-0002-8445-5082
dc.contributor.authorOgutcu, Hatice
dc.contributor.authorMeral, Seher
dc.contributor.authorCeker, Selcuk
dc.contributor.authorAgar, Aysen Alaman
dc.contributor.authorAgar, Guleray
dc.date.accessioned2025-03-23T19:30:04Z
dc.date.available2025-03-23T19:30:04Z
dc.date.issued2021
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, we aimed to investigate for the first time antimicrobial and antimutagenic activities new two Schiff bases, obtained from a primary amine (p-toluidine, o-toluidine) and an aldehyde (Helicin). Synthesized compounds characterized with elemental analysis, fourier transform infrared spectroscopy, ultraviolet-visible spectrophotometry. H-1-C-13 nuclear magnetic resonance spectroscopy. Antimutagenic activity was evaluated by micronuclei assay. Antimicrobial activity of Schiff bases have been demonstrated against pathogenic four Gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermis, Micrococcus luteus, Bacillus cereus) and four Gram-negative bacteria (Pseudumonas aeroginosa, Salmonella typhi H, Brucella abortus, Escherichia coli) and two yeasts (Candida albicans and Saccharomyces cerevisiae). The results showed that both Schiff bases have antimutagenic activity. Especially, high concentration (20 mu M) of (E)-2-(hydroxymethyl)-6-(2-((p-tolylimino)methyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol (Compound I) and (E)-2-(hydroxymethyl)-6-(2-((o-tolylimino)methyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol (Compound II) have strong antimutagenic activity against aflatoxin B-1. On the other hand, both of studied compounds were found effective against pathogenic bacteria and yeasts. Compound I exhibited more activity against P. aeroginosa, S aureus, S.typhi H and C. albicans comparable to Compound II and standard antibiotics. Additionally, Compound II showed better inhibitory activity than Compound I against Candida albicans and Br. Abortus. Therefore, these compounds can be used in phytotherapeutic due to theirs antimutagenic and antimicrobial activities.
dc.identifier.doi10.1590/0001-3765202120191432
dc.identifier.issn0001-3765
dc.identifier.issn1678-2690
dc.identifier.issue3
dc.identifier.pmid34287457
dc.identifier.scopus2-s2.0-85110518575
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/0001-3765202120191432
dc.identifier.urihttps://hdl.handle.net/11486/5001
dc.identifier.volume93
dc.identifier.wosWOS:000677487800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcad Brasileira De Ciencias
dc.relation.ispartofAnais Da Academia Brasileira De Ciencias
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectAnti-microbial activity
dc.subjectelemental analysis
dc.subjectgenotoxicity
dc.subjecthelicin
dc.subjectpathogenic strains
dc.subjectSchiff bases
dc.titleDetermination of antimicrobial and antimutagenic properties of some Schiff bases
dc.typeArticle

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