Caffeine Habituation, Not CYP1A2 Genotype, Modulates the Acute Effect of Caffeine on Exercise-Induced Hemostatic Responses in Adults with Obesity

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dc.contributor.authorSajedi, Heidar
dc.contributor.authorAydin, Elif
dc.contributor.authorKeskin, Ozlem
dc.contributor.authorErcis, Sertac
dc.contributor.authorAkpinar, Selahattin
dc.contributor.authorKhodadadi, Davar
dc.date.accessioned2026-04-25T14:20:18Z
dc.date.available2026-04-25T14:20:18Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractPurpose: This study aimed to investigate how genotype and caffeine habituation influence the acute effects of caffeine ingestion on exercise-induced hemostatic responses in individuals with obesity. Methods: Using a randomized, double-blind, placebo-controlled crossover design, 40 physically inactive young men with obesity (age, 22.2 +/- 2.3 yr; body mass index, 34.1 +/- 2.7 kgm(-2)) completed two moderate-to-high-intensity concurrent exercise sessions following ingestion of caffeine (3 mgkg(-1)) or placebo. Blood samples were collected at baseline, after exercise, and after 60 min of recovery. Statistical analysis was performed by repeated-measures multivariate analysis of variance. Results: Acute exercise increased platelet count and aggregation, fibrinogen, F1 + 2, tPA antigen, D-dimer, and clot lysis time, regardless of genotype or caffeine habituation status (P < 0.05). PAI-1 antigen remained unchanged after exercise (P > 0.05) but decreased following recovery (P < 0.01). Caffeine resulted in a greater increase in platelet aggregation, fibrinogen, F1 + 2, and clot lysis time, alongside a blunted increase in tPA antigen levels post-exercise in na & iuml;ve consumers (P < 0.05). In contrast, habitual caffeine consumers exhibited a mitigated increase in clot lysis time and a greater post-recovery reduction in PAI-1 antigen following caffeine ingestion (P < 0.001). Caffeine's impact on hemostatic responses to exercise was unaffected by genotype (P > 0.05). Conclusions: Moderate-to-high-intensity concurrent exercise induces a transient prothrombotic state in physically inactive individuals with obesity. Acute caffeine supplementation at a moderate dose modulates the hemostatic responses depending on caffeine habituation status rather than CYP1A2 genotype: it exacerbates the prothrombotic response in na & iuml;ve consumers but attenuates it in habitual consumers.
dc.identifier.doi10.1249/MSS.0000000000003816
dc.identifier.endpage2666
dc.identifier.issn0195-9131
dc.identifier.issn1530-0315
dc.identifier.issue12
dc.identifier.pmid40638809
dc.identifier.scopus2-s2.0-105010770774
dc.identifier.scopusqualityQ1
dc.identifier.startpage2656
dc.identifier.urihttps://doi.org/10.1249/MSS.0000000000003816
dc.identifier.urihttps://hdl.handle.net/11486/8496
dc.identifier.volume57
dc.identifier.wosWOS:001680273100034
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMedicine & Science in Sports & Exercise
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260420
dc.subjectCAFFEINE
dc.subjectCONCURRENT EXERCISE
dc.subjectOBESITY
dc.subjectPLATELET AGGREGATION
dc.subjectCOAGULATION
dc.subjectFIBRINOLYSIS
dc.titleCaffeine Habituation, Not CYP1A2 Genotype, Modulates the Acute Effect of Caffeine on Exercise-Induced Hemostatic Responses in Adults with Obesity
dc.typeArticle

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