Antitumor effects of novel nickel-hydrazone complexes in lung cancer cells

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dc.authoridLopez-de-Luzuriaga, Jose M./0000-0001-5767-8734
dc.authoridSaygideger, Yasemin/0000-0003-3293-373X
dc.authoridSaygideger Demir, Burcu/0000-0001-5179-0522
dc.authoridAY, BURAK/0000-0001-7055-8139
dc.authoridMahmoudi, Ghodrat/0000-0002-4846-5283
dc.contributor.authorAy, Burak
dc.contributor.authorSahin, Onur
dc.contributor.authorDemir, Burcu Saygideger
dc.contributor.authorSaygideger, Yasemin
dc.contributor.authorLopez-de-Luzuriaga, Jose M.
dc.contributor.authorMahmoudi, Ghodrat
dc.contributor.authorSafin, Damir A.
dc.date.accessioned2025-03-23T19:35:42Z
dc.date.available2025-03-23T19:35:42Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractIn this work we have synthesized and characterized two new mononuclear nickel(ii) complexes [NiLI]center dot CH3CN (1 center dot CH3CN) and [Ni(H2LII)(NCS)(2)]center dot 0.5H(2)O (2 center dot 0.5H(2)O), fabricated from a mixture of Ni(NO3)(2) and KNCS with N ',N '''-(1,2-diphenylethane-1,2-diylidene)di(picolinohydrazide) (H2LI) and 1,2-diphenyl-1,2-bis(((pyridin-2-yl)methylene)hydrazono)ethane (Lig), of which the latter one was transformed in situ into methyl-N-(3,4-diphenyl-5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-4-yl)picolinohydrazonate (H2LII) upon coordination to the metal center under synthetic conditions in methanol. The nickel(ii) atom in the structure of complex 1 is tetracoordinated and in a N3O geometry, formed by one doubly deprotonated ligand L-I, linked through the pyridyl nitrogen atom, one of the amide nitrogen atoms, one of the imine nitrogen atoms and one of the carbonyl oxygen atoms, yielding an almost perfect square-planar coordination environment. The crystal packing of 1 center dot CH3CN is dictated by a set of weak non-covalent interactions, namely C-HMIDLINE HORIZONTAL ELLIPSISO, C-HMIDLINE HORIZONTAL ELLIPSIS pi and pi MIDLINE HORIZONTAL ELLIPSIS pi stacking interactions. The asymmetric unit of complex 2 center dot 0.5H(2)O contains two crystallographically independent complex molecules [Ni(H2LII)(NCS)(2)], namely 2-I and 2-II, which are geometrically very similar. The metal atoms are six-coordinated and in a N-6 geometry, formed by one neutral ligand H2LII, linked through two pyridyl nitrogen atoms, one amine nitrogen atom from the pyrazole ring, one imidate nitrogen and two NCS- nitrogen atoms, yielding a distorted octahedral coordination environment. The crystal packing of 2 center dot CH3CN is mainly dictated by intermolecular N-HMIDLINE HORIZONTAL ELLIPSISN, N-HMIDLINE HORIZONTAL ELLIPSISS and O-HMIDLINE HORIZONTAL ELLIPSISS hydrogen bonds, yielding a 3D framework, which is further stabilized by intermolecular pi MIDLINE HORIZONTAL ELLIPSIS pi stacking interactions. From the topological point of view, the hydrogen bonded 3D framework of 2 center dot 0.5H(2)O reveals a four-connected uninodal crb/BCT; 4/4/t5; sqc184 topology. In in vitro experiments, both complexes showed dose dependent cytotoxicity and killed A549 lung cancer cells via an apoptotic pathway. Both complexes also reduced the expression of Snail2, leading to an increase in E-cadherin expression and inhibiting the motility of the cells. The complexes were determined as potential antitumor agents.
dc.description.sponsorshipTurkish Thoracic Society [Y-173-2018]; D.G.I. MINECO/FEDER [CTQ2016-75816-C2-2-P]
dc.description.sponsorshipWe are grateful to the University of Maragheh and the authors acknowledge the Scientific and Technological Research Application and Research Center (Sinop University, Turkey) for the use of the Bruker D8 QUEST diffractometer. In vitro experiments were partially supported by Turkish Thoracic Society Grant Y-173-2018. Jose M. Lopez-de-Luzuriaga acknowledges D.G.I. MINECO/FEDER (project number CTQ2016-75816-C2-2-P (AEI/FEDER, UE)) for financial support.
dc.identifier.doi10.1039/d0nj00921k
dc.identifier.endpage9072
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.issue21
dc.identifier.scopus2-s2.0-85085730978
dc.identifier.scopusqualityQ2
dc.identifier.startpage9064
dc.identifier.urihttps://doi.org/10.1039/d0nj00921k
dc.identifier.urihttps://hdl.handle.net/11486/5911
dc.identifier.volume44
dc.identifier.wosWOS:000539351700044
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofNew Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectDna/Protein Interaction
dc.subjectLead(Ii) Architectures
dc.subjectCrystal-Structures
dc.subjectMolecular Docking
dc.subjectChemistry
dc.subjectHistory
dc.subjectBinding
dc.subjectNi(Ii)
dc.titleAntitumor effects of novel nickel-hydrazone complexes in lung cancer cells
dc.typeArticle

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