Antitumor effects of novel nickel-hydrazone complexes in lung cancer cells
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Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Royal Soc Chemistry
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this work we have synthesized and characterized two new mononuclear nickel(ii) complexes [NiLI]center dot CH3CN (1 center dot CH3CN) and [Ni(H2LII)(NCS)(2)]center dot 0.5H(2)O (2 center dot 0.5H(2)O), fabricated from a mixture of Ni(NO3)(2) and KNCS with N ',N '''-(1,2-diphenylethane-1,2-diylidene)di(picolinohydrazide) (H2LI) and 1,2-diphenyl-1,2-bis(((pyridin-2-yl)methylene)hydrazono)ethane (Lig), of which the latter one was transformed in situ into methyl-N-(3,4-diphenyl-5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-4-yl)picolinohydrazonate (H2LII) upon coordination to the metal center under synthetic conditions in methanol. The nickel(ii) atom in the structure of complex 1 is tetracoordinated and in a N3O geometry, formed by one doubly deprotonated ligand L-I, linked through the pyridyl nitrogen atom, one of the amide nitrogen atoms, one of the imine nitrogen atoms and one of the carbonyl oxygen atoms, yielding an almost perfect square-planar coordination environment. The crystal packing of 1 center dot CH3CN is dictated by a set of weak non-covalent interactions, namely C-HMIDLINE HORIZONTAL ELLIPSISO, C-HMIDLINE HORIZONTAL ELLIPSIS pi and pi MIDLINE HORIZONTAL ELLIPSIS pi stacking interactions. The asymmetric unit of complex 2 center dot 0.5H(2)O contains two crystallographically independent complex molecules [Ni(H2LII)(NCS)(2)], namely 2-I and 2-II, which are geometrically very similar. The metal atoms are six-coordinated and in a N-6 geometry, formed by one neutral ligand H2LII, linked through two pyridyl nitrogen atoms, one amine nitrogen atom from the pyrazole ring, one imidate nitrogen and two NCS- nitrogen atoms, yielding a distorted octahedral coordination environment. The crystal packing of 2 center dot CH3CN is mainly dictated by intermolecular N-HMIDLINE HORIZONTAL ELLIPSISN, N-HMIDLINE HORIZONTAL ELLIPSISS and O-HMIDLINE HORIZONTAL ELLIPSISS hydrogen bonds, yielding a 3D framework, which is further stabilized by intermolecular pi MIDLINE HORIZONTAL ELLIPSIS pi stacking interactions. From the topological point of view, the hydrogen bonded 3D framework of 2 center dot 0.5H(2)O reveals a four-connected uninodal crb/BCT; 4/4/t5; sqc184 topology. In in vitro experiments, both complexes showed dose dependent cytotoxicity and killed A549 lung cancer cells via an apoptotic pathway. Both complexes also reduced the expression of Snail2, leading to an increase in E-cadherin expression and inhibiting the motility of the cells. The complexes were determined as potential antitumor agents.
Açıklama
Anahtar Kelimeler
Dna/Protein Interaction, Lead(Ii) Architectures, Crystal-Structures, Molecular Docking, Chemistry, History, Binding, Ni(Ii)
Kaynak
New Journal of Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
44
Sayı
21
