Efficacy of Extracorporeal Shockwaves Therapy on Peripheral Nerve Regeneration

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dc.authoridM.Bakhit, Nagi/0000-0003-3509-7247
dc.authoridsagir, dilek/0000-0002-6862-988X
dc.contributor.authorSagir, Dilek
dc.contributor.authorBereket, Cihan
dc.contributor.authorOnger, Mehmet Emin
dc.contributor.authorBakhit, Nagi
dc.contributor.authorKeskin, Metehan
dc.contributor.authorOzkan, Enes
dc.date.accessioned2025-03-23T19:34:16Z
dc.date.available2025-03-23T19:34:16Z
dc.date.issued2019
dc.departmentSinop Üniversitesi
dc.description.abstractPurpose: This study was conducted to determine the effects of different doses and methods of extracorporeal shock wave treatment (ESWT) on the sciatic nerve regeneration of rat model using unbiased quantitative stereological techniques and to know which method and dose were effective. Methods: Twenty-five Wistar albino rats were used in the experiment. All animals were randomly divided into 5 groups. To the first group (control, n = 5) ESWT and surgery were not applied. To 2nd group (E300*2, n = 5), twice doses of 300 impulses uESWs (unfocused) were applied. To 3rd group (E500*2, n = 5), twice doses of 500 impulses uESWs (unfocused) were applied. To 4th group (E300*2, n = 5), twice doses of 300 impulses of fESWs (focused) were applied. To 5th group (E500*2, n = 5), twice doses of 500 impulses of fESWs (focused) were applied. Rats were sacrificed and nerve samples analyzed on the 22nd day following the operation. Results: There is a variable increase in the axon numbers among the shockwave treated groups in compare to the control group. The focused groups showed better improvement and the 300-focused group has shown the highest regeneration rate. Conclusion: The authors found that ESWT promotes nerve regeneration, increases the thickness of the myelin sheath and that the most effective result is in the 300 shock wave.
dc.identifier.doi10.1097/SCS.0000000000005671
dc.identifier.endpage2639
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue8
dc.identifier.pmid31577651
dc.identifier.scopus2-s2.0-85074619820
dc.identifier.scopusqualityQ3
dc.identifier.startpage2635
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000005671
dc.identifier.urihttps://hdl.handle.net/11486/5639
dc.identifier.volume30
dc.identifier.wosWOS:000509687200133
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Craniofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectExtracorporeal shock waves therapy
dc.subjecthistology
dc.subjectperipheral nerve regeneration
dc.subjectstereology
dc.titleEfficacy of Extracorporeal Shockwaves Therapy on Peripheral Nerve Regeneration
dc.typeArticle

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