Poly-L-lysine modified cryogels for efficient bilirubin removal from human plasma

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dc.authoridCorman, Mehmet Emin/0000-0001-9062-4201
dc.authoridCORMAN, MEHMET EMIN/0000-0003-2202-7266
dc.contributor.authorCorman, Mehmet Emin
dc.date.accessioned2025-03-23T19:41:51Z
dc.date.available2025-03-23T19:41:51Z
dc.date.issued2018
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, poly-L-lysine (PLL) immobilized PHEMA cryogel was designed for the specific bilirubin removal from human plasma. The surface of PHEMA cryogels is surrounded by PLL chains to enhance specific binding of bilirubin molecules via specific complementary electrostatic interactions. The functionalization of the PHEMA cryogel was carried out by direct coupling of PLL to pre-activated OH-group of the HEMA alcohol units via carbodiimide activation. Prior to removal of bilirubin from human plasma, the optimization parameters including, initial bilirubin concentration, flow rate, temperature, ionic strength, and adsorption rates on adsorption of PLL-PHEMA cryogel were investigated from the aqueous medium. According to the elemental analyses results, the incorporation of PLL was 690.0 mu mol/g cryogel. The cryogel has highly interconnected supermacroporous structure sized between 20 and 100 mu m with a positive surface charge value. The maximum bilirubin adsorption capacity was found as 59.9 mg/g of the dry weight of PLL-PHEMA cryogel. Reusability study explored that PLL-PHEMA could be used with a negligible loss in the bilirubin adsorption capacity after successive ten adsorption-desorption cycles using the same adsorbent. The results of the study demonstrated that the PLL-PHEMA cryogel exhibited high specificity that can be used as an efficient column for removing the bilirubin from the human plasma. (C) 2018 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.colsurfb.2018.04.019
dc.identifier.endpage298
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.pmid29679805
dc.identifier.scopus2-s2.0-85045584320
dc.identifier.scopusqualityQ1
dc.identifier.startpage291
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2018.04.019
dc.identifier.urihttps://hdl.handle.net/11486/6661
dc.identifier.volume167
dc.identifier.wosWOS:000434747200034
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCorman, Mehmet Emin
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofColloids and Surfaces B-Biointerfaces
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectPoly-L-lysine
dc.subjectCryogel
dc.subjectAffinity binding
dc.subjectBilirubin
dc.subjectHuman plasma
dc.titlePoly-L-lysine modified cryogels for efficient bilirubin removal from human plasma
dc.typeArticle

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