A histopathological and stereological study of the effects of acetylsalicylic acid on doxorubicin-induced hepatotoxicity in mice

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dc.authoridsagir, dilek/0000-0002-6862-988X
dc.contributor.authorGokce, Ayse Basardi
dc.contributor.authorEren, Banu
dc.contributor.authorSagir, Dilek
dc.contributor.authorYilmaz, Burcu Demirel
dc.date.accessioned2025-03-23T19:34:56Z
dc.date.available2025-03-23T19:34:56Z
dc.date.issued2021
dc.departmentSinop Üniversitesi
dc.description.abstractDoxorubicin (Dox) is an anthracycline antibiotic with antineoplastic activity. Acetylsalicylic acid (Asa) is recommended for use as a prophylactic for thromboembolism during treatment of cancers. We investigated liver toxicity due to combined use of Dox and Asa in chemotherapy regimens. We used 140 Swiss albino mice divided into four main groups: control, Dox, Asa, and Dox + Asa. Each group was subdivided into seven subgroups based on time of sacrifice, i.e., 6, 12, 24, 48 h and 7, 14, 21 days. Quantitative and histopathological changes in liver were assessed by light microscopy and stereology. The portal triad area of the Dox and Dox + Asa groups was increased significantly compared to controls at 6 h, whereas in the Asa group, the means were similar to controls. Assessment of histopathology indicated an increased time-dependent degeneration and necrosis of liver tissues in mice in the Dox and Dox + Asa groups. The protective effects of Asa were not evident in Dox + Asa group. When Dox and Asa were administered together, degenerative changes were greater than for in the group that was given Dox alone. We found that Asa and Dox combined therapy increased tissue damage.
dc.identifier.doi10.1080/10520295.2020.1788724
dc.identifier.endpage256
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4
dc.identifier.pmid32643434
dc.identifier.scopus2-s2.0-85087814634
dc.identifier.scopusqualityQ2
dc.identifier.startpage251
dc.identifier.urihttps://doi.org/10.1080/10520295.2020.1788724
dc.identifier.urihttps://hdl.handle.net/11486/5770
dc.identifier.volume96
dc.identifier.wosWOS:000547044200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectAcetylsalicylic acid
dc.subjectdoxorubicin
dc.subjecthistopathology
dc.subjectliver
dc.subjectmice
dc.subjectstereology
dc.titleA histopathological and stereological study of the effects of acetylsalicylic acid on doxorubicin-induced hepatotoxicity in mice
dc.typeArticle

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