Synthesis and Characterization of Novel Organocobaloximes as Potential Catecholase and Antimicrobial Activity Agents

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dc.authoridKaripcin, Fatma/0000-0002-4939-2514
dc.contributor.authorErdem-Tuncmen, Mukadder
dc.contributor.authorKaripcin, Fatma
dc.contributor.authorSariboga, Bahtiyar
dc.date.accessioned2025-03-23T19:47:16Z
dc.date.available2025-03-23T19:47:16Z
dc.date.issued2013
dc.departmentSinop Üniversitesi
dc.description.abstractAn asymmetric, potentially bidentate dioxime ligand (H2L) was formed by condensation of 4-biphenylchloroglyoxime and napthyl-1-amine. Two equivalents of H2L were reacted with CoCl(2)6H(2)O under appropriate conditions with deprotonation of the dioxime ligand. A series of new organocobaloxime derivatives of the type [CoR(HL)(2)Py], [CoRL2PyB2F4], and [CoRL2Py(Cu(phen))(2)] (H2L=4-(napthyl-1-amino)biphenylglyoxime; phen=1,10-phenathroline; R=izopropyl and benzyl; Py=pyridine) were synthesized. The products were characterized by elemental analysis, molar conductance, FT-IR, H-1 NMR, and magnetic susceptibility measurements. Catecholase-like activity properties of all complexes were also studied. All complexes are catalysts for the oxidation of 3,5-di-tert-butylcatechol to 3,5-di-tert-butyl-1,2-benzoquinone in methanol. Antimicrobial activity studies of H2L and the six complexes were carried out on standard strains (human pathogenic) of bacteria (Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Bacillus cereus, Enterococcus faecalis, Streptococcus pneumoniae, Listeria monocytogenes, Bacillus subtilis, Escherichia coli, Pseudominas aeruginosa, Salmonella typhi) and the yeast Candida albicans. The compounds showed a significant inhibition of the growth of the Gram-positive bacteria tested. Among the tested microorganisms, S. aureus was the most sensitive strain, especially to H2L and its complexes.
dc.description.sponsorshipSuleyman Demirel University, (Isparta/Turkey) [1505-D-07]
dc.description.sponsorshipThis work was supported by the Research Fund of Suleyman Demirel University, Project no: 1505-D-07 (Isparta/Turkey).
dc.identifier.doi10.1002/ardp.201300168
dc.identifier.endpage726
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.issue10
dc.identifier.pmid24003018
dc.identifier.scopus2-s2.0-84885675316
dc.identifier.scopusqualityQ1
dc.identifier.startpage718
dc.identifier.urihttps://doi.org/10.1002/ardp.201300168
dc.identifier.urihttps://hdl.handle.net/11486/7322
dc.identifier.volume346
dc.identifier.wosWOS:000325497500003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofArchiv Der Pharmazie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectAntimicrobial activity
dc.subjectCatecholase activity
dc.subjectMultinuclear
dc.subjectOrganocobaloxime
dc.titleSynthesis and Characterization of Novel Organocobaloximes as Potential Catecholase and Antimicrobial Activity Agents
dc.typeArticle

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